A role of the neural coordination between the gustatory and autonomic insula.

• Project/Area Number: 25462884
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Functional basic dentistry
• Research Institution: Osaka University
• Principal Investigator: Hajime Sato 大阪大学, 歯学研究科, 助教 (10432452)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: 味覚 / 島皮質 / 自律神経反応 / オシレーション / アナンダミド / カプサイシン / 味覚野 / 自律機能 / GPR119 / 国際情報交換 / 韓国 / 機能協関 / 自律神経中枢 / 膜電位測光法 / 自律神経関連領野

Outline of Final Research Achievements

I have examined the neural coordination between the dysgranular region in the insular cortex, which is involved in taste perception as the primary gustatory area (Gu-I), and the granular region in the insular cortex, which is potentially involved in visceral sensory-motor control as the primary autonomic area (Au-I). In a series of in vitro (J Neurosci. 2012) and human fMRI studies (Front. Hum. Neurosci. 2016), it is demonstrated that the neural coordination between these two areas may be involved in autonomic responses to tasting spicy foods. Ｆurthermore, by using voltage sensitive dye imaging, it is demonstrated that the neural coordination between the Gu-I and the gastrointestinal region of Au-I is generated or suppressed by the opposing activities between CB1R and GPR119 (Sci Rep. 2016). This mechanism may be involved in the feeding behavior based on taste recognition. It will be possible that the neural coordination between Gu-I and Au-I play multi-functional roles.

Research Products

• [Journal Article] A distinct functional distribution of α and γ motoneurons in the rat trigeminal motor nucleus. (2017)
  • Author(s): Morita-Isogai, Y., Sato, H., Saito, M., Kuramoto, E., Yin, D., Kaneko, T., Yamashiro, T., Takada, K., Oh, S.B., Toyoda, H., & Kang, Y.
  • Journal Title: Brain Structure and Function Volume: - Issue: 7 Pages: 1-9
  • DOI: 10.1007/s00429-017-1400-8
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The possible role of TASK channels in rank-ordered recruitment of motoneurons in the dorsolateral part of the trigeminal motor nucleus. (2016)
  • Author(s): Okamoto, K., Emura, N., Sato, H., Fukatsu, Y., Saito, M., Tanaka, C., Morita, Y., Nishimura, K., Kuramoto, E., Yin, D., Furutani, K., Okazawa, M., Kurachi, Y., Kaneko, T., Maeda, Y., Yamashiro, T., Takada, K., Toyoda, H. & Kang, Y.
  • Journal Title: eNeuro Volume: 3(3)
  • Peer Reviewed / Open Access
• [Journal Article] A role of CB1R in inducing θ-rhythm coordination between the gustatory and gastrointestinal insula. (2016)
  • Author(s): Kang, Y., Sato, H., Saito, M.,Yin, D., Park, S.K., Oh, S.B., Bae, Y.C. & Toyoda, H.
  • Journal Title: Scientific Reports Volume: 6 Issue: 1 Pages: 32529-32529
  • DOI: 10.1038/srep32529
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The Brain Mechanisms Underlying the Perception of Pungent Taste of Capsaicin and the Subsequent Autonomic Responses (2016)
  • Author(s): Shinpei Kawakami, Hajime Sato, Akihiro T. Sasaki, Hiroki C. Tanabe, Yumiko Yoshida, Mitsuru Saito, Hiroki Toyoda, Norihiro Sadato and Youngnam Kang
  • Journal Title: Frontiers in Human Neuroscience Volume: 9 Pages: 1-16
  • DOI: 10.3389/fnhum.2015.00720
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Enhanced lateral inhibition in the barrel cortex by deletion of phospholipase C-related catalytically inactive protein-1/2 in mice. (2015)
  • Author(s): Toyoda, H., Saito, M., Sato, H., Kawano, T., Kawakami, S., Yatani, H., Kanematsu, T., Hirata, M. & Kang, Y.
  • Journal Title: Pflugers Archiv : European journal of physiology. Volume: 1 Pages: 1-1
  • Peer Reviewed
• [Journal Article] Enhanced desensitization followed by unusual resensitization in GABAA receptors in phospholipase C-related catalytically inactive protein-1/2 double-knockout mice (2014)
  • Author(s): Toyoda H, Saito M, Sato H, Tanaka T, Ogawa T, Yatani H, Kawano T, Kanematsu T, Hirata M, Kang Y
  • Journal Title: Pflugers Archiv - European Journal of Physiology Volume: (Epub ahead of print) Issue: 2 Pages: 267-284
  • DOI: 10.1007/s00424-014-1511-5
  • Peer Reviewed / Open Access
• [Journal Article] Enhanced desensitization followed by unusual resensitization in GABAA receptors in phospholipase C-related catalytically inactive protein-1/2 double-knockout mice (2014)
  • Author(s): Toyoda, H., Saito, M., Sato, H., Tanaka, T., Ogawa, T., Yatani, H., Kawano, T., Kanematsu, T., Hirata, M. & Kang, Y
  • Journal Title: Pflugers Archiv - European Journal of Physiology. Volume: In press
  • Peer Reviewed
• [Journal Article] Teeth clenching reduces arm abduction force. (2014)
  • Author(s): Sato, H., Kawano, T., Saito, M., Toyoda, H., Maeda, Y., Turker, K.S. & Kang, Y.
  • Journal Title: Experimental Brain Research Volume: In press
• [Journal Article] A mathematical model of negative covariability of inter-columnar excitatory synaptic actions caused by presynaptic inhibition (2013)
  • Author(s): Saito M, Tanaka T, Sato H, Toyoda H, Aoyagi T, Kang Y
  • Journal Title: The European Journal of euroscience Volume: 38 Issue: 7 Pages: 2999-3007
  • DOI: 10.1111/ejn.12299
  • Peer Reviewed
• [Presentation] アナンダミドにより島皮味覚野と胃腸自律領野間にネットワークオシレーションが誘発される (2017)
  • Author(s): 豊田博紀、佐藤元、尹東旭、姜英男
  • Organizer: 第94回 日本生理学会大会
  • Place of Presentation: アクトシティ浜松（静岡県浜松市）
  • Year and Date: 2017-03-28
• [Presentation] Role of anandamide-induced network oscillation in the insular cortex in causing taste-driven feeding (2016)
  • Author(s): Sato, H., Yin, D., Toyoda, H., Kang, Y.
  • Organizer: Oral Neuroscience 2016
  • Place of Presentation: 大阪大学（大阪府吹田市）
  • Year and Date: 2016-10-01
  • Int'l Joint Research
• [Presentation] カプサイシンの辛味認知とそれに伴う自律神経反応を担う脳機構 (2015)
  • Author(s): 佐藤 元
  • Organizer: 第57回歯科基礎医学会学術大会
  • Place of Presentation: 朱鷺メッセ（新潟県・新潟市）
  • Year and Date: 2015-09-11
• [Presentation] The neural mechanisms involved in the perception of burning taste of capsaicin and subsequent autonomic responses (2015)
  • Author(s): Hajime Sato, Shinpei Kawakami, Mitsuru Saito, Hiroki Toyoda, Tsutomu Kawano, DongXu Yin, Norihiro Sadato and Youngnam Kang
  • Organizer: ISNO 2015
  • Place of Presentation: 大阪大学中ノ島センター
  • Year and Date: 2015-05-10 – 2015-05-11
• [Presentation] Anandamide-induced network oscillation in the insular cortex implicated in taste-driven feeding (2015)
  • Author(s): Hajime Sato
  • Organizer: The International Symposium on Neuroscience in Orofacial sensory-motor functions 2015
  • Place of Presentation: 大阪大学中ノ島センター（大阪府・大阪市）
  • Year and Date: 2015-05-10
• [Presentation] カプサイシンの辛味認知およびそれに伴う自律神経系の活性化に関与する神経機構 (2014)
  • Author(s): 佐藤元、川上晋平、豊田博紀、斉藤充、河野奨、姜英男
  • Organizer: 第56回歯科基礎医学会学術大会
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] 光学的膜電位測定によって観察されたラットバレル野における周期的同期化 (2013)
  • Author(s): 佐藤元
  • Organizer: 歯科基礎医学会
  • Place of Presentation: 岡山コンベンションセンター
• [Presentation] 光学的膜電位測定によって観察されたラットバレル野第2/3層神経活動のGABAB受容体依存的ペアドパルス抑制 (2013)
  • Author(s): 佐藤元
  • Organizer: Neuro2013
  • Place of Presentation: 国立京都国際会館
• [Remarks] 大阪大学大学院歯学研究科 高次脳口腔機能学講座ホームページ 研究業績
  • URL: http://web.dent.osaka-u.ac.jp/~phys/publ.html
• [Remarks] 大阪大学大学院歯学研究科 口腔生理学教室ホームページ
  • URL: http://web.dent.osaka-u.ac.jp/~phys/
• [Remarks] 大阪大学 大学院歯学研究科統合機能口腔科学専攻 高次脳口腔機能学講座 口腔生理学教室ホームページ
  • URL: http://web.dent.osaka-u.ac.jp/~phys/
• [Remarks] 口腔生理学教室ホームページ
  • URL: http://web.dent.osaka-u.ac.jp/~phys/