Grant-in-Aid for Scientific Research (C)
I have examined the neural coordination between the dysgranular region in the insular cortex, which is involved in taste perception as the primary gustatory area (Gu-I), and the granular region in the insular cortex, which is potentially involved in visceral sensory-motor control as the primary autonomic area (Au-I). In a series of in vitro (J Neurosci. 2012) and human fMRI studies (Front. Hum. Neurosci. 2016), it is demonstrated that the neural coordination between these two areas may be involved in autonomic responses to tasting spicy foods. Ｆurthermore, by using voltage sensitive dye imaging, it is demonstrated that the neural coordination between the Gu-I and the gastrointestinal region of Au-I is generated or suppressed by the opposing activities between CB1R and GPR119 (Sci Rep. 2016). This mechanism may be involved in the feeding behavior based on taste recognition. It will be possible that the neural coordination between Gu-I and Au-I play multi-functional roles.
Brain Struct Funct
Frontiers in human neuroscience
Pflugers Archiv : European journal of physiology.
Pflügers Archiv–Eur. J. Physiol.
Volume: (Epub ahead of print)
Pflugers Archiv - European Journal of Physiology.
Volume: In press
Experimental Brain Research
The European Journal of Neuroscience.
Attribution of KAKENHI