| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
In the present study, we studied the mechanism of nerve paralysis by focusing on the role of leak K+ channels expressed in motoneurons. Following application of 8-Br-cGMP, input resistances were decreased and spike onsets were delayed in small-sized motoneurons (< 20 μm), while input resistances and spike onsets remained almost unchanged in large-sized motoneurons (> 35 μm). These results suggest that activation of NO-cGMP-PKG pathway alters membrane excitability of motoneurons through the modulation of activities of leak K+ currents. Such neural mechanisms are likely to be involved in the generation of neural paralysis.
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