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Role of trigeminal-mediated reflex on the hemodynamics in the brain during mastication and their modulation mediated by central nervous system

Research Project

Project/Area Number 25462896
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Functional basic dentistry
Research InstitutionHealth Sciences University of Hokkaido

Principal Investigator

Ishii Hisayoshi  北海道医療大学, 歯学部, 教授 (00275489)

Co-Investigator(Kenkyū-buntansha) SATO Toshiya  北海道医療大学, 歯学部, 講師 (30709241)
NIIOKA Takeharu  北海道医療大学, 薬学部, 准教授 (10382491)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords咀嚼 / 脳血流 / 三叉神経 / 自律神経 / 血管拡張反応 / GABA受容体 / 副交感性血管拡張反応 / GABAA受容体 / 脳虚血疾患 / コリン作動性血管拡張線維 / 非コリン作動性血管拡張線維 / VIP / GABA / 内頸動脈
Outline of Final Research Achievements

The present study was designed to examine the role of trigeminal-mediated reflex on the hemodynamics in the brain during mastication and its relationship with brain functions or dysfunctions induced by cerebral ischemia. For these purposes, we investigated 1) role of parasympathetic vasodilation on the cerebral hemodynamics, 2) response characteristics of the vasodilation and 3) effect of GABA systems on the hemodynamics in the brain. Our results indicate that the increase in blood flow in the brain are evoked by parasympathetic vasodilation via the trigeminal-mediated reflex. These increases are thought to be regulated by the GABA systems in the central nervous system. These results suggest that the parasympathetic reflex vasodilation and its modulation mediated by GABA systems in the brain are important factors in the etiology of dysfunctions induced by cerebral ischemia.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (23 results)

All 2016 2015 2014 2013 Other

All Journal Article (4 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (15 results) (of which Invited: 2 results) Book (1 results) Remarks (3 results)

  • [Journal Article] Differences in control of parasympathetic vasodilation between submandibular and sublingual glands in the rat2015

    • Author(s)
      Sato T and Ishii H
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol

      Volume: 309 Issue: 11 Pages: R1432-R1438

    • DOI

      10.1152/ajpregu.00306.2015

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] 口腔・顔面・頭部領域の自律神経性血流調節とOrofacial painを伴う機能障害との関連性-咀嚼筋の自律神経性血流調節を中心にして-2014

    • Author(s)
      石井久淑
    • Journal Title

      北医療大デンタルトピックス(総説)

      Volume: 45 Pages: 1-11

    • Related Report
      2014 Research-status Report
  • [Journal Article] Parasympathetic reflex vasodilation in the cerebral hemodynamics of rats2014

    • Author(s)
      Ishii H, Sato T, Izumi H
    • Journal Title

      J Comp Physiol B

      Volume: 184 Issue: 3 Pages: 385-399

    • DOI

      10.1007/s00360-014-0807-2

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] ラット咬筋の基礎血流調節に対するサブスタンスPの作用2013

    • Author(s)
      新岡丈治、石井久淑
    • Journal Title

      北医療大歯誌

      Volume: 32 Pages: 21-31

    • NAID

      120005456725

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Parasympathetic vasodilation in major salivary glands in type 2 diabetic rats2016

    • Author(s)
      Sato T and Ishii H
    • Organizer
      Proceedings of the 93rd Annual Meeting of The Physiological Society of Japan
    • Place of Presentation
      札幌コンベンションセンター, Sapporo, Japan
    • Year and Date
      2016-03-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] Involvement of the autonomic vasomotor responses on the thermoregulation in the orofacial area2016

    • Author(s)
      Ishii H and Sato T
    • Organizer
      Proceedings of the 93rd Annual Meeting of The Physiological Society of Japan
    • Place of Presentation
      札幌コンベンションセンター, Sapporo, Japan
    • Year and Date
      2016-03-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] Interactions between parasympathetic vasodilation and systemic arterial blood pressure in the hemodynamics in the orofacial area2015

    • Author(s)
      Ishii H and Sato T
    • Organizer
      第57回歯科基礎医学会学術大会
    • Place of Presentation
      朱鷺メッセ、新潟
    • Year and Date
      2015-09-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] ラット 3 大唾液腺における副交感神経性血流増加反応の相違2015

    • Author(s)
      佐藤寿哉、石井久淑
    • Organizer
      第57回歯科基礎医学会学術大会-サテライトシンポジウム「第29回唾液腺談話会唾液腺研究最前線~未来へと続く軌跡~」
    • Place of Presentation
      朱鷺メッセ、新潟
    • Year and Date
      2015-09-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] ラット3大唾液腺で生じる副交感神経性血流増加反応の相違2015

    • Author(s)
      佐藤寿哉、石井久淑
    • Organizer
      第95回北海道医学大会生理系分科会
    • Place of Presentation
      旭川医科大学、北海道
    • Year and Date
      2015-09-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] The interaction between ACh and VIP on parasympathetic blood flow increase in rat sublingual gland2015

    • Author(s)
      Sato T and Ishii H
    • Organizer
      Proceedings of the 120th Annual Meeting of The Japanese Association of Anatomists and the 92nd Annual Meeting of The Physiological Society of Japan
    • Place of Presentation
      神戸国際会議場・展示場, Kobe, Japan
    • Year and Date
      2015-03-22
    • Related Report
      2014 Research-status Report
  • [Presentation] Activation of α2-adrenoceptors via cervical sympathetic nerve involves β-adrenergic vasodilation in the masseter muscle mediated by sympathoadrenal system2015

    • Author(s)
      Ishii H and Sato T
    • Organizer
      Proceedings of the 120th Annual Meeting of The Japanese Association of Anatomists and the 92nd Annual Meeting of The Physiological Society of Japan
    • Place of Presentation
      神戸国際会議場・展示場, Kobe, Japan
    • Year and Date
      2015-03-22
    • Related Report
      2014 Research-status Report
  • [Presentation] 頸部交感神経は交感神経―副腎系から分泌される循環アドレナリンを介する咀嚼筋の血流増加に関与する2014

    • Author(s)
      石井久淑、佐藤寿哉
    • Organizer
      第56回歯科基礎医学会学術大会
    • Place of Presentation
      福岡国際会議場、福岡
    • Year and Date
      2014-09-27
    • Related Report
      2014 Research-status Report
  • [Presentation] ラット舌下腺における副交感神経性血流増加反応に関与するAchとVIPの相互作用2014

    • Author(s)
      佐藤寿哉、石井久淑
    • Organizer
      第56回歯科基礎医学会学術大会
    • Place of Presentation
      福岡国際会議場、福岡
    • Year and Date
      2014-09-26
    • Related Report
      2014 Research-status Report
  • [Presentation] ラット顎下腺と舌下腺の異なる副交感神経性血流増加反応機序2014

    • Author(s)
      佐藤寿哉、石井久淑
    • Organizer
      第94回北海道医学大会生理系分科会
    • Place of Presentation
      北海道大学、北海道
    • Year and Date
      2014-08-30
    • Related Report
      2014 Research-status Report
  • [Presentation] Orofacial painを伴う慢性的な機能障害と副交感神経性血流増加反応との関連性

    • Author(s)
      石井久淑
    • Organizer
      北海道医療大学歯学部同窓会学術講演会
    • Place of Presentation
      札幌第一ホテル、北海道
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 顎・顔面領域の自律神経反応の特殊性 -自律神経性血流調節を中心にして-

    • Author(s)
      石井久淑
    • Organizer
      第19回日本胸腔鏡下交感神経遮断研究会
    • Place of Presentation
      NTT東日本札幌病院ペインクリニックセンター、北海道
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 脳血流動態における三叉―副交感神経性血管拡張反応の役割とそれらのGABA入力による機能修飾機構

    • Author(s)
      石井久淑、佐藤寿哉
    • Organizer
      第55回歯科基礎医学会学術大会
    • Place of Presentation
      岡山コンベンションセンター、岡山
    • Related Report
      2013 Research-status Report
  • [Presentation] Interaction of sympathoadrenal system and cervical sympathetic nerves mediated by adrenergic and NPY receptors on the hemodynamics in the jaw muscle

    • Author(s)
      Ishii H and Sato T
    • Organizer
      The Proceedings of the 91st Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      鹿児島大学郡元キャンパス, Kagoshima, Japan
    • Related Report
      2013 Research-status Report
  • [Presentation] The localization of parasympathetic vasodilator fibers related to blood flow dynamics in rat salivary gland

    • Author(s)
      Sato T and Ishii H
    • Organizer
      The Proceedings of the 91st Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      鹿児島大学郡元キャンパス, Kagoshima, Japan
    • Related Report
      2013 Research-status Report
  • [Book] 基礎歯科生理学2014

    • Author(s)
      石井久淑
    • Total Pages
      486
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2014 Research-status Report
  • [Remarks] 北海道医療大学歯学部口腔生物学系生理学分野

    • URL

      http://www.hoku-iryo-u.ac.jp/~physiol/

    • Related Report
      2015 Annual Research Report
  • [Remarks] 北海道医療大学 歯学部 口腔生物学系生理学分野

    • URL

      http://www.hoku-iryo-u.ac.jp/~physiol/

    • Related Report
      2014 Research-status Report
  • [Remarks] 北海道医療大学 歯学部 口腔生物学系生理学分野

    • URL

      http://www.hoku-iryo-u.ac.jp/~physiol/

    • Related Report
      2013 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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