| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Bone formation by osteoblasts and bone resorption by osteoclasts are balanced to maintain bone homeostasis. Enhanced bone resorption can lead to bone fracture seen in osteoporosis. We found that rhinacanthin C isolated from R.nasutus has a strong anti-osteoclast formation effect. Rhinacanthin C dose-dependently and reversibly suppressed RANKL-induced osteoclast differentiation and expression of NFATc1, which is an essential transcription factor for osteoclast differentiation. Rhinacanthin C also suppressed endotoxin LPS-stimulated osteoclastogenesis from cultured bone marrow cells. Furthermore, rhinacanthin C protected RANKL or LPS induced mouse calvarial osteolysis in vivo.
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