Inhibitory mechanism of rhinacanthin C on osteoclast formation
| Project/Area Number |
25462898
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Functional basic dentistry
|
|---|
| Research Institution | Meikai University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
Shirataki Yoshiaki 城西大学, 薬学部, 教授 (60077980)
Suzuki Ryuichiro 城西大学, 薬学部, 助教 (20415201)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | 破骨細胞 / 骨吸収 / 骨粗鬆症 / 生薬 / シグナル伝達 / 生薬由来化合物 / 骨代謝 |
|---|
| Outline of Final Research Achievements |
Bone formation by osteoblasts and bone resorption by osteoclasts are balanced to maintain bone homeostasis. Enhanced bone resorption can lead to bone fracture seen in osteoporosis. We found that rhinacanthin C isolated from R.nasutus has a strong anti-osteoclast formation effect. Rhinacanthin C dose-dependently and reversibly suppressed RANKL-induced osteoclast differentiation and expression of NFATc1, which is an essential transcription factor for osteoclast differentiation. Rhinacanthin C also suppressed endotoxin LPS-stimulated osteoclastogenesis from cultured bone marrow cells. Furthermore, rhinacanthin C protected RANKL or LPS induced mouse calvarial osteolysis in vivo.
|
Report
(4 results)
Research Products
(10 results)
