Elucidation of molecular mechanisms for osteoclast polarization through Wnt5a-Ror2 signaling
Project/Area Number |
25462904
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Functional basic dentistry
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Research Institution | Matsumoto Dental University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Yasuhiro 松本歯科大学, 総合歯科医学研究所, 教授 (20264252)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Keywords | 破骨細胞 / Wnt / 非古典経路 / 骨吸収 / Rho / 極性化 / Wnt非古典経路 / Wnt5a / Ror2 |
Outline of Final Research Achievements |
Polarization of osteoclasts (formation of actin rings and ruffled borders) is necessary to resorb bone. We examined the molecular mechanisms regulating osteoclast polarization through the cytokine Wnt5a and co-receptor Ror2 in osteoclasts. We revealed that Wnt5a-Ror2 signaling regulates the bone-resorbing activity of osteoclasts through the activation of Rho-Pkn3 pathways, and that Daam2, an adaptor molecule, is involved in activation of Rho under the Ror2 signaling.
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] Noncanonical Wnt5a enhances Wnt/-catenin signaling during osteogenesis.2014
Author(s)
Okamoto, M., Udagawa, N., Yamashita, T., Nakamichi, Y., Uehara, S., Kato, H., Saito, N., Minami, Y., Takahashi, N., Kobayashi, Y.
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Journal Title
Sci. report
Volume: 4
Issue: 1
Pages: 4493-4493
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Rho-Pkn3 pathway regulates the bone-resorbing activity of osteoclasts under Wnt5a-Ror2 signaling2015
Author(s)
Uehara S, Mukai H, Yamashita T, Nakamura T, Kato S, Kikuchi A, Nishita M, Minami Y, Udagawa N, Takahashi N, Kobayashi Y
Organizer
第37回アメリカ骨代謝学会(ASBMR)
Place of Presentation
ワシントン州コンベンションセンター アメリカ シアトル
Year and Date
2015-10-10
Related Report
Int'l Joint Research
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[Presentation] Wnt5a-Ror2 signal regulates function of osteoclasts through Daam2-Rho pathway2014
Author(s)
Uehara S, Ishihara A, Maeda K, Yamashita T, Nakamura T, Kato S, Kikuchi A, Nishita M, Minami Y, Udagawa N, Takahashi N, Kobayashi Y
Organizer
第5回International conference on osteoimmunology
Place of Presentation
へロナリゾート ギリシャ コス島
Year and Date
2014-06-16
Related Report
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[Presentation] Wnt5a-Ror2 signal regulates osteoclast polarization through Daam2 and Rho
Author(s)
Uehara S, Ishihara A, Maeda K, Yamashita T, Nakamura T, Imai Y, Kato S, Kikuchi A, Nishita M, Minami Y, Udagawa N, Takahashi N, Kobayashi Y
Organizer
国際骨代謝学会(IBMS)・日本骨代謝学会第2回合同学術集会
Place of Presentation
神戸コンベンションセンター(神戸市)
Related Report
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