Roles of an atypical Wnt receptor, Ryk, for bone remodeling

• Project/Area Number: 25462905
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Functional basic dentistry
• Research Institution: Matsumoto Dental University
• Principal Investigator: Nakamichi Yuko 松本歯科大学, 総合歯科医学研究所, 講師 (20350829)
• Co-Investigator(Kenkyū-buntansha): Udagawa Nobuyuki 松本歯科大学, 歯学部, 教授 (70245801)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: Ryk / Wnt / 破骨細胞 / 骨芽細胞 / 骨細胞

Outline of Final Research Achievements

Wnt signaling is involved in virtually every aspect of embryonic development, and also homeostatic self-renewal and aging in a variety of adult tissues. Ryk is the latest member of the Wnt receptors. Ryk does not belong to the conventional classification of the Wnt-promoted signal transduction. Therefore, little is known about its mechanism of action. Ryk may be involved in Wnt-regulated processes in bone remodeling. In this study, we elucidated roles of Ryk for bone and mineral metabolism by using Ryk conditional KO mice lines that are established in our laboratory.

Research Products

• [Journal Article] 歯髄細胞に関する分子生物学的研究 (2016)
  • Author(s): 中道裕子、高橋直之、宇田川信之
  • Journal Title: 腎と骨代謝 Volume: ２９ Pages: 31-39
  • NAID: 120006422721
• [Journal Article] 活性型ビタミンDの骨リモデリング制御系における作用 (2015)
  • Author(s): 中道裕子、高橋直之
  • Journal Title: Clinical Calcium Volume: ２５ Pages: 395-402
• [Journal Article] Wnt16 regulates osteoclast differentiation in conjunction with Wnt5a. (2015)
  • Author(s): Kobayashi Y, Thirukonda GJ, Nakamura Y, Koide M, Yamashita T, Uehara S, Kato H, Udagawa N, Takahashi N
  • Journal Title: Biochem Biophys Res Commun Volume: 463 Issue: 4 Pages: 1278-1283
  • DOI: 10.1016/j.bbrc.2015.06.102
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The regulation of osteoclast differentiation by Wnt signals (2015)
  • Author(s): Kobayashi Y, Uehara S, Koide M, Takahashi N
  • Journal Title: Bonekey Rep Volume: 4 Issue: 4 Pages: 713-713
  • DOI: 10.1093/jb/mvv124
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 活性型ビタミンＤの骨リモデリング制御系における作用 (2015)
  • Author(s): 中道裕子，高橋直之
  • Journal Title: クリニカルカルシウム Volume: 25 Pages: 395-402
• [Journal Article] oles of cathelicidins in inflammation and bone loss. (2014)
  • Author(s): Nakamichi Y, Horibe K, Udagawa N, Takahashi N
  • Journal Title: Odontology Volume: １０１ Issue: 2 Pages: 137-146
  • DOI: 10.1007/s10266-014-0167-0
  • Peer Reviewed / Open Access
• [Journal Article] Noncanonical Wnt5a enhances Wnt/-catenin signaling during osteogenesis. (2014)
  • Author(s): Okamoto, M., Udagawa, N., Yamashita, T., Nakamichi, Y., Uehara, S., Kato, H., Saito, N., Minami, Y., Takahashi, N., Kobayashi, Y.
  • Journal Title: Sci. report Volume: 4 Issue: 1 Pages: 4493-4493
  • DOI: 10.1038/srep04493
  • Peer Reviewed / Open Access
• [Journal Article] Roles of cathelicidin-related antimicrobial peptide in murine osteoclastogenesis (2013)
  • Author(s): Horibe K, Kobayashi Y, Takahashi N, Udagawa N(他4名)
  • Journal Title: Immunology Volume: 140 Issue: 3 Pages: 344-351
  • DOI: 10.1111/imm.12146
  • Peer Reviewed / Open Access
• [Journal Article] IL-34 and CSF-1 similarities and differences (2013)
  • Author(s): Nakamichi Y, Udagawa N, Takahashi N
  • Journal Title: J Bone Miner Metab Volume: 31 Issue: 5 Pages: 486-495
  • DOI: 10.1007/s00774-013-0476-3
  • NAID: 10031201682
  • Peer Reviewed / Open Access
• [Journal Article] Vitamin D receptor in osteoblasts is a negative regulator of bone mass control (2013)
  • Author(s): Yamamoto Y, Yoshizawa T, Fukuda T, Shirode-Fukuda Y, Yu T, Sekine K, Sato T, Kawano H, Aihara K, Naka michi Y, Watanabe T, Shindo M, Inoue K, Inoue E, Tsuji N, Hoshino M, Karsenty G, Metzger D, Chambon P, Kato S, Imai Y.
  • Journal Title: Endocrinology. Volume: 154 Issue: 3 Pages: 1008-20
  • DOI: 10.1210/en.2012-1542
  • Peer Reviewed
• [Presentation] 活性型ビタミンDによる骨量上昇の薬理作用は、骨芽細胞系列のビタミンD 受容体(VDR)を介して発揮される (2016)
  • Author(s): 中道裕子
  • Organizer: 第1回日本骨免疫学会ウインターセミナー
  • Place of Presentation: ホテルマロウド （長野県）
  • Year and Date: 2016-01-28
• [Presentation] 活性型ビタミンD製剤エルデカルシトールは，骨芽細胞と骨細胞のVDRを介して骨吸収を抑制し、骨量を増加させる (2015)
  • Author(s): 中道裕子
  • Organizer: 第33回日本骨代謝学会学術集会
  • Place of Presentation: 京王プラザホテル (東京都）
  • Year and Date: 2015-07-25
• [Presentation] 活性型ビタミンDによる骨量上昇の薬理作用は、骨芽細胞系列のビタミンD 受容体(VDR)を介して発揮される (2015)
  • Author(s): 中道裕子
  • Organizer: 第1回 日本骨免疫学会
  • Place of Presentation: ホテルブリーズベイマリーナ （沖縄県）
  • Year and Date: 2015-06-30
• [Presentation] 硬組織再生におけるヒト歯髄細胞と骨髄間葉細胞の有用性についての比較解析 (2014)
  • Author(s): 中道裕子，徳田吉彦，萩原貴寛，堀部寛治，中村美どり，高橋直之，宇田川信之
  • Organizer: 日本骨免疫会議
  • Place of Presentation: 万国津梁館（沖縄県名護市）
  • Year and Date: 2014-07-04
• [Presentation] Spleen serves as a reservoir of osteoclast precursors in op/op mice
  • Author(s): 中道 裕子
  • Organizer: 第１０回 Bone Biology Forum
  • Place of Presentation: 富士教育研究所 (静岡県裾野市)
  • Invited
• [Book] 骨ペディア 骨疾患・骨代謝キーワード事典 日本骨代謝学会編, 「M-CSF/IL-34」 (2015)
  • Author(s): 中道裕子、宇田川信之 他
  • Total Pages: 327
  • Publisher: 羊土社