| Project/Area Number |
25462909
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Hokkaido University |
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Principal Investigator |
Ono Mitsunobu 北海道大学, 大学病院, 講師 (50281829)
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| Co-Investigator(Kenkyū-buntansha) |
OHGA Noritaka 北海道大学, 大学院歯学研究科, 助教 (40548202)
KITAMURA Tetsuya 北海道大学, 大学院歯学研究科, 助教 (00451451)
SHINDOH Masanobu 北海道大学, 大学院歯学研究科, 教授 (20162802)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 腫瘍血管内皮細胞 / Biglycan / プロテオグリカン / 腫瘍マーカー |
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| Outline of Final Research Achievements |
We focused on biglycan which is proteoglycan and a published-tumor endothelial markers. Since the function of biglycan has not been fully evaluated, we addressed the role of biclycan in tumor vasculature in oral cancer in this study. We showed that biglycan is involved in tumor endothelial cell migration. The biglycan plasma level was elevated in cancer patients compared to that in normal volunteer. Finally, we tried to establish the system for targeting biglycan in tumor endothelial cells using drug delivery system which contains biglycan siRNA.
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