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Preventing complications from high-dose rate brachytherapy during the treatment of mobile tongue cancer via the application of a modular lead-lined spacer

Research Project

Project/Area Number 25462917
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionOsaka University

Principal Investigator

Murakami Shumei  大阪大学, 歯学研究科(研究院), 准教授 (00263301)

Co-Investigator(Kenkyū-buntansha) KAKIMOTO Naoya  大阪大学, 歯学部附属病院, 講師 (50324794)
UCHIYAMA Yuka  大阪大学, 大学院歯学研究科, 助教 (80322171)
TSUJIMOTO Tomomi  大阪大学, 大学院歯学研究科, 助教 (00632150)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords放射線治療 / 組織内照射 / 舌癌 / スペーサ / 小線源治療
Outline of Final Research Achievements

The purpose of this study was to point out the advantages and drawbacks of high-dose rate brachytherapy in the treatment of mobile tongue cancer and indicate the clinical importance of modular lead-lined spacers when applying this technique to patients. First, all basic steps to construct the modular spacer are shown. Second, we simulate and evaluate the dose rate reduction for a wide range of spacer configurations.
With increasing distance to the source absorbed doses dropped considerably. Significantly more shielding was obtained when lead was added to the spacer and this effect was most pronounced on shorter (i.e. more clinically relevant) distances to the source. In conclusion, the modular spacer represents an important addition to the planning and treatment stages of mobile tongue cancer using HDR-ISBT.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (9 results)

All 2016 2015 2014 2013 Other

All Int'l Joint Research (1 results) Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (6 results) (of which Int'l Joint Research: 1 results,  Invited: 2 results)

  • [Int'l Joint Research] Craniofacial Imaging Institute(Denmark)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Preventing complications from high-dose rate brachytherapy during the treatment of mobile tongue cancer via the application of a modular lead-lined spacer2016

    • Author(s)
      Shumei Murakami, Rinus G. Verdonschot, Naoya Kakimoto, Iori Sumida, Masateru Fujiwara, Kazuhiko Ogawa, Souhei Furukawa
    • Journal Title

      PLOS ONE

      Volume: in press

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Evaluation of imaging performance of megavoltage cone-beam CT over an extended period2014

    • Author(s)
      Sumida I, Yamaguchi H, Kizaki H, Yamada Y, Koizumi M, Yoshioka Y, Ogawa K, Kakimoto N, Murakami S, Furukawa S.
    • Journal Title

      J Radiat Res.

      Volume: 55 Issue: 1 Pages: 191-9

    • DOI

      10.1093/jrr/rrt100

    • Related Report
      2014 Research-status Report 2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 口腔癌の診断と治療2016

    • Author(s)
      村上秀明
    • Organizer
      第45回教育研修会(2016年口腔四学会合同研修会)
    • Place of Presentation
      横浜・鶴見大学記念館
    • Year and Date
      2016-02-27
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] A MODULAR SPACER FOR THE TREATMENT AND 3D-CT PLANNING OF TONGUE CANCER USING INTERSTITIAL BRACHYTHERAPY2015

    • Author(s)
      Tomita-S, Murakami-S, Tsujimoto-T, Shimamoto-H, Kakimoto-N
    • Organizer
      2015 ICDMFR, The 20th International Congress of Dento-Maxillo-Facial Radiology
    • Place of Presentation
      Santiago, Chile
    • Year and Date
      2015-08-28
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 高線量率組織内照射による舌癌放射線治療時の新しいスペーサ2015

    • Author(s)
      村上秀明ら
    • Organizer
      日本歯科放射線学会 第56回学術大会
    • Place of Presentation
      仙台
    • Year and Date
      2015-06-05 – 2015-06-07
    • Related Report
      2014 Research-status Report
  • [Presentation] 高線量率組織内照射による舌癌放射線治療時の新しいスペーサ2015

    • Author(s)
      村上秀明、柿本直也、笹井正思、中谷温紀、島本博彰、辻本友美、岡畑諒子、丸谷佳右、岩本悠里、古川惣平
    • Organizer
      日本歯科放射線学会 第56回学術集会
    • Place of Presentation
      仙台・戦災復興記念館
    • Year and Date
      2015-06-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] Evaluation of scatter doses from dental metals2013

    • Author(s)
      Shimamoto-H, Sumida-I, Okahata-R, Tsujimoto-T, Kakimoto-N, Murakami-S, Furukawa-S
    • Organizer
      64th AAOMR
    • Place of Presentation
      Los Angeles, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] Radiation therapy for tongue cancer2013

    • Author(s)
      Murakami-S
    • Organizer
      2013 Chonnam National University Special Seminar
    • Place of Presentation
      Gwangju, KOREA
    • Related Report
      2013 Research-status Report
    • Invited

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Published: 2014-07-25   Modified: 2019-07-29  

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