Analysis of new functions of an intracellular protease in epithelial cancers
Project/Area Number |
25462920
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Pathobiological dentistry/Dental radiology
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Research Institution | Nagasaki University |
Principal Investigator |
FUKUMA Yutaka 長崎大学, 医歯薬学総合研究科(歯学系), 技術職員 (50253688)
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Co-Investigator(Kenkyū-buntansha) |
TSUKUBA Takayuki 長崎大学, 医歯薬学総合研究科(歯学系), 教授 (30264055)
OKAMOTO Kuniaki 長崎大学, 医歯薬学総合研究科(歯学系), 准教授 (10311846)
NISHISHITA Kazuhisa 長崎大学, 医歯薬学総合研究科(歯学系), 助教 (20237697)
SAKAI Eiko 長崎大学, 医歯薬学総合研究科(歯学系), 助教 (10176612)
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Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 上皮性癌 / プロテアーゼ / カテプシン / 癌 / 細胞内プロテアーゼ |
Outline of Final Research Achievements |
There are many studies reported relationship between cancer and proteases. For a long time, proteases have been recognized as bad factors for cancer progression. However, we discovered that cathepsin E prevents cancer progression as a good factor. In this study, we found that cathepsin E deficiency developed mammary tumors, and identified the altered genes and proteins in the cathepsin E-deficient mammary cells. As a result, Wnt5a was significantly impaired in the deficient mammary cells. Therefore, cathepsin E deficiency may cause abnormal Wnt/β-catenin signaling, thereby resulting in cancer development.
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Report
(4 results)
Research Products
(40 results)
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[Journal Article] Kadowaki T, Kido MA, Hatakeyama J, Okamoto K, Tsukuba T, Yamamoto K. Defective adipose tissue development associated with hepatomegaly in cathepsin E-deficient mice fed a high-fat diet.2014
Author(s)
Kadowaki T, Kido MA, Hatakeyama J, Okamoto K, Tsukuba T, Yamamoto K.
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Journal Title
Biochem Biophys Res Commun.
Volume: 446(1)
Issue: 1
Pages: 212-217
DOI
Related Report
Peer Reviewed
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[Journal Article] Cathepsin E in mammary gland: Repression of cathepsin E expression increases the risk of mammary carcinogenesis and links to poor prognosis in breast cancer.2013
Author(s)
Tomoyo Kawakubo, Atsushi Yasukochi, Tatsuya Toyama, Satoru Takahashi, Kuniaki Okamoto, Takayuki Tsukuba, Seiji Nakamura, Yasuhiko Ozaki, Koichi Nishigaki, Hiroko Yamashita, and Kenji Yamamoto
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Journal Title
Carcinogenesis
Volume: 00
Issue: 3
Pages: 1-13
DOI
Related Report
Peer Reviewed / Open Access
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