| Project/Area Number |
25462920
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Nagasaki University |
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Principal Investigator |
FUKUMA Yutaka 長崎大学, 医歯薬学総合研究科(歯学系), 技術職員 (50253688)
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| Co-Investigator(Kenkyū-buntansha) |
TSUKUBA Takayuki 長崎大学, 医歯薬学総合研究科(歯学系), 教授 (30264055)
OKAMOTO Kuniaki 長崎大学, 医歯薬学総合研究科(歯学系), 准教授 (10311846)
NISHISHITA Kazuhisa 長崎大学, 医歯薬学総合研究科(歯学系), 助教 (20237697)
SAKAI Eiko 長崎大学, 医歯薬学総合研究科(歯学系), 助教 (10176612)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 上皮性癌 / プロテアーゼ / カテプシン / 癌 / 細胞内プロテアーゼ |
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| Outline of Final Research Achievements |
There are many studies reported relationship between cancer and proteases. For a long time, proteases have been recognized as bad factors for cancer progression. However, we discovered that cathepsin E prevents cancer progression as a good factor. In this study, we found that cathepsin E deficiency developed mammary tumors, and identified the altered genes and proteins in the cathepsin E-deficient mammary cells. As a result, Wnt5a was significantly impaired in the deficient mammary cells. Therefore, cathepsin E deficiency may cause abnormal Wnt/β-catenin signaling, thereby resulting in cancer development.
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