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Role of MUC1 regulated by stress-responsed micro RNA

Research Project

Project/Area Number 25462923
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionNagasaki University

Principal Investigator

TASHIRO Shigeki  長崎大学, 病院(歯学系), 助教 (20300882)

Co-Investigator(Kenkyū-buntansha) HOTOKEZAKA Yuka  長崎大学, 病院(歯学系), 講師 (10244089)
KATAYAMA Ikuo  長崎大学, 医歯薬学総合研究科(歯学系), 助教 (80295089)
ICHIKAWA Yoko  長崎大学, 病院(歯学系), 助教 (90380857)
NAKAMURA Takashi  長崎大学, 医歯薬学総合研究科(歯学系), 教授 (30172406)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
KeywordsMUC1 / マイクロRNA / ストレス応答 / cPLA2 / GAP結合
Outline of Final Research Achievements

MUC1 is a transmembrane glycoprotein that modulates transcription via its cytoplasmic domain. We originally paid attention to the MUC1 function under the environmental stresses such as ionizing radiation, UV, heat-shock, Hypoxia. Particularly we think that MUC1 expression control through the micro RNA may take the role that is important to stress correspondence.
As a result of having inspected it about a reply to hypoxia about the MUC1 protein, in HeLa S3 cell cultured under a hypoxia, an expression of MUC1 level decreased within 2 hours after a culture start and decreased in the level that expression of MUC1 could not detect in 6 hours later. After transfecting siRNA of the cause protein candidate -alpha NAC and gamma taxilin, MUC1 expression level decreased, the data which suggested positively were provided.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (1 results)

All 2013

All Presentation (1 results)

  • [Presentation] cPLA2コンディショナル ノックアウトマウスの作成2013

    • Author(s)
      田代茂樹
    • Organizer
      日本歯科放射線学会
    • Place of Presentation
      福岡県立ももち文化センター(ももちパレス)(福岡県福岡市早良区百道二丁目3番15号)
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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