| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
Squamous cell cancers in head and neck are known to be sensitive to irradiation. Patients may have oral-sequelae to radiation include mucositis and salivary glands dysfunction. Some groups have shown protective effects of D-methionine, the dextro-isomer of the common amino acid L-methionine, against oxidative stress. To evaluate if D-methionine can prevent oral mucositis and salivary glands dysfunction resulting from x-ray irradiation or carbon ion beam during treatment for the head and neck cancers. D-methionine can prevent irradiation-induced oral mucositis or salivary glands dysfunction in mice and may be useful clinically to prevent such oral mucositis or xerostomia in head and neck cancer patients.
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