• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Application of 11beta-HSD1 inhibitors to the treatment of periodontal disease

Research Project

Project/Area Number 25462941
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionOsaka Dental University

Principal Investigator

SAWAI Hirofumi  大阪歯科大学, 歯学部, 講師 (40298823)

Co-Investigator(Kenkyū-buntansha) MASUZAKI Hiroaki  琉球大学, 大学院医学研究科, 教授 (00291899)
UMEDA Makoto  大阪歯科大学, 歯学部, 教授 (90193937)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords歯周病 / 慢性歯周炎 / メタボリック症候群 / 11β-HSD1 / グルココルチコイド / コルチゾール / 慢性炎症 / 肥満 / 歯学 / メタボリックシンドローム / 11β-HSD1 / コルチゾル / 11β-HSD1
Outline of Final Research Achievements

11β-HSD1, which converts inactive cortisone to active cortisol intracellularly, has been reported to play a pivotal role in metabolic diseases as well as chronic inflammatory diseases. However, the involvement of 11β-HSD1 in chronic periodontitis has not been investigated. In this study the relationship between chronic periodontitis, the levels of 11β-HSD1 mRNA, and obesity was examined. The expression of 11β-HSD1 mRNA was significantly higher in the chronic periodontitis group than in the controls. Since the expression of 11β-HSD2 mRNA, which inactivates cortisol, was slightly lower in the periodontitis group than in the controls, the ratio of 11β-HSD1 versus 11β-HSD2 mRNA was still higher in the former than in the latter. However, a correlation was not observed between the levels of 11β-HSD1 mRNA and body mass index, an index of obesity. These results suggest that the increased 11β-HSD1 may play a role in the pathology of chronic periodontitis irrespective of obesity.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (12 results)

All 2016 2015 2014 2013

All Journal Article (8 results) (of which Peer Reviewed: 8 results,  Open Access: 1 results,  Acknowledgement Compliant: 4 results) Presentation (4 results)

  • [Journal Article] The increased ratio of 11β-hydroxysteroid dehydrogenase type 1 versus 11β-hydroxysteroid dehydrogenase type 2 in chronic periodontitis irrespective of obesity2016

    • Author(s)
      Nakata T, Fujita A, Umeda M, Yoshida H, Inami K, Masuzaki H, Sawai H
    • Journal Title

      SpringerPlus

      Volume: 5 Issue: 1

    • DOI

      10.1186/s40064-016-1679-6

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Differential changes in sphingolipids between TNF-induced necroptosis and apoptosis in U937 cells and necroptosis-resistant sublines2015

    • Author(s)
      Sawai H, Ogiso H, Okazaki T
    • Journal Title

      Leukemia Research

      Volume: 39 Issue: 9 Pages: 964-970

    • DOI

      10.1016/j.leukres.2015.06.002

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Characterization of TNF-induced caspase-independent necroptosis.2014

    • Author(s)
      Sawai H.
    • Journal Title

      Leukemia Research

      Volume: 38 Issue: 6 Pages: 706-713

    • DOI

      10.1016/j.leukres.2014.02.002

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] An inhibitory role for caspase-3 at the late stage of RANKL-induced osteoclast differentiation in RAW264 cells and mouse bone marrow macrophages.2014

    • Author(s)
      Katao Y, Shishido M, Inami K, Matsumoto N, Sawai H.
    • Journal Title

      Cell Biology International

      Volume: 38 Issue: 6 Pages: 723-728

    • DOI

      10.1002/cbin.10263

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Differential effects of caspase inhibitors on TNF-induced necroptosis、Biochemical and Biophysical2013

    • Author(s)
      Hirofumi Sawai
    • Journal Title

      Research Communications

      Volume: 432 Issue: 3 Pages: 451-455

    • DOI

      10.1016/j.bbrc.2013.01.126

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Involvement of 11β-HSD1 in metabolic syndrome and periodontal disease.2013

    • Author(s)
      Shiraishi M, Sawai H, Nagano Y, Ueda M, Umeda M.
    • Journal Title

      J Osaka Dent Univ

      Volume: 7-10 Pages: 7-10

    • NAID

      110009603273

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Augmentation of RANKL-induced osteoclast differentiation by Z-VAD-fmk, a pan-caspase inhibitor.2013

    • Author(s)
      Katao Y, Sawai H, Shishido M, Omae A, Liao W, Inami K, Matsumoto N.
    • Journal Title

      J Osaka Dent Univ

      Volume: 47 Pages: 41-46

    • NAID

      110009603277

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Facilitation of experimental tooth movement by NOC-18, a long-acting nitric oxide donor2013

    • Author(s)
      Mika Shishido、Hirofumi Sawai、Kaoru Inami、 Yuko Katao 、Naoyuki Matsumoto
    • Journal Title

      Orthodontic Waves

      Volume: 72 Issue: 2 Pages: 43-48

    • DOI

      10.1016/j.odw.2012.12.001

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 歯周炎モデルラットにおける11β-HSD1発現の比較・検討2015

    • Author(s)
      中田貴也、藤田敦子、澤井宏文、益崎裕章、大久保直、梅田誠
    • Organizer
      日本歯科保存学会2015年度秋季学術大会(第143回)
    • Place of Presentation
      文京シビックホール(東京)
    • Year and Date
      2015-11-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] 慢性歯周炎における細胞内グルココルチコイド活性化酵素11β-HSD1発現の増加2015

    • Author(s)
      藤田敦子、中田貴也、澤井宏文、居波薫、吉田博昭、益崎裕章、大久保直、梅田誠
    • Organizer
      第58回秋季日本歯周病学会学術大会
    • Place of Presentation
      アクトシティ浜松(浜松市)
    • Year and Date
      2015-09-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] 歯周病における細胞内グルココルチコイド活性化酵素11β-HSD1との関連.2014

    • Author(s)
      中田貴也,澤井宏文,益崎裕章,藤田敦子,白石真教,吉田博昭,大久保 直,梅田 誠.
    • Organizer
      日本歯周病学会2014秋季学術大会(第57回)
    • Place of Presentation
      神戸国際会議場(神戸市)
    • Year and Date
      2014-10-19
    • Related Report
      2014 Research-status Report
  • [Presentation] カスパーゼ-3阻害剤による破骨細胞分化の増強.2013

    • Author(s)
      宍戸美香,澤井宏文,居波 薫,片尾祐子,西浦亜紀,松本尚之.
    • Organizer
      第72回日本矯正歯科学会大会
    • Place of Presentation
      キッセイ文化ホール(長野県松本市)
    • Related Report
      2013 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi