Application of 11beta-HSD1 inhibitors to the treatment of periodontal disease
| Project/Area Number |
25462941
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Osaka Dental University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MASUZAKI Hiroaki 琉球大学, 大学院医学研究科, 教授 (00291899)
UMEDA Makoto 大阪歯科大学, 歯学部, 教授 (90193937)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 歯周病 / 慢性歯周炎 / メタボリック症候群 / 11β－ＨＳＤ１ / グルココルチコイド / コルチゾール / 慢性炎症 / 肥満 / 歯学 / メタボリックシンドローム / １１β－ＨＳＤ１ / コルチゾル / １１β－HSD1 |
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| Outline of Final Research Achievements |
11β-HSD1, which converts inactive cortisone to active cortisol intracellularly, has been reported to play a pivotal role in metabolic diseases as well as chronic inflammatory diseases. However, the involvement of 11β-HSD1 in chronic periodontitis has not been investigated. In this study the relationship between chronic periodontitis, the levels of 11β-HSD1 mRNA, and obesity was examined. The expression of 11β-HSD1 mRNA was significantly higher in the chronic periodontitis group than in the controls. Since the expression of 11β-HSD2 mRNA, which inactivates cortisol, was slightly lower in the periodontitis group than in the controls, the ratio of 11β-HSD1 versus 11β-HSD2 mRNA was still higher in the former than in the latter. However, a correlation was not observed between the levels of 11β-HSD1 mRNA and body mass index, an index of obesity. These results suggest that the increased 11β-HSD1 may play a role in the pathology of chronic periodontitis irrespective of obesity.
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Report
(4 results)
Research Products
(12 results)
