| Project/Area Number |
25462943
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Conservative dentistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
TANAKA SAORI 北海道大学, 大学病院, 講師 (90344522)
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| Co-Investigator(Kenkyū-buntansha) |
MIYAJI HIROFUMI 北海道大学, 北海道大学病院, 講師 (50372256)
INOUE KANA 北海道大学, 北海道大学病院, 医員 (40600127)
TANAKA TORU 北海道大学, 北海道大学病院, 講師 (90179771)
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| Co-Investigator(Renkei-kenkyūsha) |
TANINO MISHIE 北海道大学, 医学研究科, 講師 (90360908)
KATO AKIHITO 北海道大学, 歯学研究科, 助教 (40507571)
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| Research Collaborator |
KANAYAMA IZUMI 北海道大学, 歯学研究科, 大学院生
NISHIDA ERIKA 北海道大学, 歯学研究科, 大学院生
MURAKMI SHUSUKE 北海道大学, 歯学研究科, 大学院生
KAWAMOTO KOHEI 北海道大学, 歯学研究科, 大学院生
MIYATA SAORI 北海道大学, 歯学研究科, 大学院生
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | ナノテクノロジー / 歯周組織再生 / カーボンナノチューブ / ナノβ-TCP / 細胞培養シート / レジン / ナノβ‐TCP |
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| Outline of Final Research Achievements |
Composite resin (CR) is used the bonding treatment of vertically fractured roots and as a retrograde material following apiccectomy. We aimed to the periodontal regeneration on CR. Effective biological modification of the CR surface is thus needed to improve its biocompatibility. Carbon nanotubes (CNT) and β-TCP have useful properties such as promoting cell adhesion and proliferation. CR discs were coated by immersion in a dispersion of CNT and β-TCP. In the cell culture assay, the CNT-CR samples exhibited abundant cells and marked adhesion of filopodia to CNT. Cell proliferation assay indicated that the CNT-CR was significantly higher than the CR . This results showed that coating the surface of CR with CNT improved their biocompatibility. In vivo studies, we observed the bone-like hard tissue formation on a CNT-CR wrapped in cultured bone marrow stromal cell sheets. Thus, this experiment might suggest a possibility of the periodontal regeneration on CR.
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