| Project/Area Number |
25462956
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Conservative dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
Miura Jiro 大阪大学, 歯学部附属病院, 助教 (70437383)
Nishi Ryuji 大阪大学, 超高圧電子顕微鏡センター, 准教授 (40243183)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 象牙質 / 破折 / コラーゲン / 加齢 / 歯根破折 / 亀裂 / 糖化 / ナノインデンテーション / 電子顕微鏡 / 石灰化組織 |
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| Outline of Final Research Achievements |
Several studies have investigated the effect of aging on the mechanism of crack propagation. They examined the cracked surface using scanning electron microscopy (SEM) to evaluate the structural modifications of dentinal microcracks with aging. Very few studies have utilized transmission electron microscopy (TEM) for sectional observation of microcracks. The purposed of this study were to morphologically evaluate the relation between dentinal microcrack propagation and human aging.
In young dentin, dentinal microcracks are propagated without interference in PTD. In contrast, in aged dentin, PTD is mature with hydroxyapatite, which prevents microcracks from propagating and they deflect around PTD. With this specimen fabrication method and TEM observation, it is possible to visualize ultra-structural propagation of microcracks within dentin, and evaluate dentinal microcrack propagation related to dentin microstructural modifications with aging.
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