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Identification and application of degraded dentin matrix components as a pulp capping agent

Research Project

Project/Area Number 25462958
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Conservative dentistry
Research InstitutionOsaka University

Principal Investigator

TAKAHASHI YUSUKE  大阪大学, 歯学部附属病院, 講師 (60397693)

Co-Investigator(Kenkyū-buntansha) TOYOSAWA SATORU  大阪大学, 歯学研究科, 教授 (30243249)
前薗 葉月  大阪大学, 歯学部附属病院, その他 (00613390)
Research Collaborator OKAMOTO MOTOKI  
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords歯学 / 覆髄 / 象牙質 / 歯髄 / 再生 / MMP分子 / 象牙質-歯髄複合体 / 第三象牙質
Outline of Final Research Achievements

Dentin matrix components (DMCs) can be degraded by proteinase like MMP molecules. Degraded DMCs by MMPs were found to promote the various functions of pulpal cells in vitro and also promote the wound healing process of dentin-pulp complex in vivo from the results of this study. Especially, degraded DMCs induced by MMP20 showed higher healing ability compared to other MMP molecules. To identify the components of the degraded DMCs by MMP20, proteome analysis was performed and eight candidate proteins were acquired from the analysis. From these results, the candidate molecules had possibilities to promote pulpal repair process and development of true biological pulp capping agent might be possible in the near future.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (14 results)

All 2015 2014 2013 Other

All Int'l Joint Research (1 results) Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (11 results) (of which Invited: 1 results)

  • [Int'l Joint Research] University of Birmingham(英国)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 次世代の歯の治療 -歯髄・根尖歯周組織の再生-① バイオロジカル歯髄創傷治癒誘導② -MMPファミリー分子-2014

    • Author(s)
      高橋雄介
    • Journal Title

      歯界展望

      Volume: 124 Pages: 104-8

    • Related Report
      2014 Research-status Report
  • [Journal Article] Chen JH. Mechanism of detoxification of the cationic antibacterial monomer 12-methacryloyloxydodecylpyridinium bromide (MDPB) by N-acetyl cysteine2013

    • Author(s)
      Ma S, Imazato S, Takahashi Y, Kiba W, Takeda K, Izutani N, Kitagawa H
    • Journal Title

      Dent Mater

      Volume: 29, 12 Issue: 12 Pages: 1219-27

    • DOI

      10.1016/j.dental.2013.09.008

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 象牙質-歯髄複合体の創傷治癒を促進する象牙質基質分解産物の同定2015

    • Author(s)
      小道俊吾, 高橋雄介, 岡本基岐, 林美加子
    • Organizer
      第143回日本歯科保存学会 2015年度秋季学術大会
    • Place of Presentation
      文京シビックホール(東京都文京区)
    • Year and Date
      2015-11-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] 生物学的根拠に基づく覆髄剤の開発2015

    • Author(s)
      岡本基岐, 高橋雄介, 小道俊吾, 林美加子
    • Organizer
      第15回日本歯内療法学会西日本支部会研修会
    • Place of Presentation
      大阪歯科大学附属病院および大阪歯科大学創立100周年記念館(大阪市)
    • Year and Date
      2015-09-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] MMP分子により分解された象牙質基質が象牙質歯髄複合体の創傷治癒に与える影響2015

    • Author(s)
      岡本基岐, 高橋雄介, 小道俊吾, 林美加子
    • Organizer
      第142回日本歯科保存学会 2015年度春季学術大会
    • Place of Presentation
      北九州国際会議場および 西日本総合展示場(小倉市)
    • Year and Date
      2015-06-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] UVA活性リボフラビンによるヒト象牙質の強化効果2015

    • Author(s)
      上村怜央, 新野侑子, 岡本基岐, 高橋雄介, 林美加子
    • Organizer
      第142回日本歯科保存学会 2015年度春季学術大会
    • Place of Presentation
      北九州国際会議場および 西日本総合展示場(小倉市)
    • Year and Date
      2015-06-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] Effect of degraded dentin matrix components on tertiary dentinogenesis2015

    • Author(s)
      Okamoto M, Takahashi Y, Komichi S, Hayashi M
    • Organizer
      93rd General Session & Exhibirion of the IADR
    • Place of Presentation
      Boston, USA
    • Year and Date
      2015-03-11
    • Related Report
      2014 Research-status Report
  • [Presentation] Mechanism of detoxification of the cationic antibacterial monomer 12-methacryloyloxydodecylpyridinium bromide (MDPB) by N-acetyl cystene2015

    • Author(s)
      Ma S, Chen JH, Imazato S, Takahashi Y, Kiba W, Takeda K, Izutani N, Kitagawa H
    • Organizer
      The 6th International Congress on Adhesive Dentistry
    • Place of Presentation
      Bangkok, Thailand
    • Year and Date
      2015-01-31
    • Related Report
      2014 Research-status Report
  • [Presentation] S-PRGフィラー含有試作セメントの覆髄剤としての応用2014

    • Author(s)
      岡本基岐, 高橋雄介, 小道俊吾, 今里 聡, 林 美加子
    • Organizer
      第140回日本歯科保存学会 2014年度春季学術大会
    • Place of Presentation
      大津
    • Year and Date
      2014-06-20
    • Related Report
      2014 Research-status Report
  • [Presentation] MMPファミリー分子と象牙質-歯髄複合体の創傷治癒

    • Author(s)
      高橋雄介
    • Organizer
      第138回日本歯科保存学会 2013年度春季学術大会 シンポジウムI
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] MMP分子により分解された象牙質基質タンパクがラット歯髄細胞に与える影響

    • Author(s)
      岡本基岐, 高橋雄介, 小道俊吾, 林 美加子
    • Organizer
      第139回日本歯科保存学会 2013年度秋季学術大会
    • Place of Presentation
      秋田県総合生活文化会館
    • Related Report
      2013 Research-status Report
  • [Presentation] MMP分子で分解を受けた象牙質基質タンパクが歯髄細胞に与える影響

    • Author(s)
      岡本基岐, 高橋雄介, 小道俊吾, 林 美加子
    • Organizer
      第13回日本再生医療学会総会
    • Place of Presentation
      国立京都国際会館
    • Related Report
      2013 Research-status Report
  • [Presentation] レーザーによりデンタルバイオフィルムを制御して、新規治療法・予防法の開発・臨床応用へ

    • Author(s)
      野杁由一郎, 朝日陽子, 高橋雄介, 恵比須繁之, 林 美加子
    • Organizer
      大阪大学未来戦略機構シンポジウム「Opt Osaka 2014 in Tokyo-大阪大学の光科学100-」
    • Place of Presentation
      東京大手町サンケイプラザ
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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