Identification and application of degraded dentin matrix components as a pulp capping agent
| Project/Area Number |
25462958
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Conservative dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TOYOSAWA SATORU 大阪大学, 歯学研究科, 教授 (30243249)
前薗 葉月 大阪大学, 歯学部附属病院, その他 (00613390)
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| Research Collaborator |
OKAMOTO MOTOKI
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 歯学 / 覆髄 / 象牙質 / 歯髄 / 再生 / MMP分子 / 象牙質－歯髄複合体 / 第三象牙質 |
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| Outline of Final Research Achievements |
Dentin matrix components (DMCs) can be degraded by proteinase like MMP molecules. Degraded DMCs by MMPs were found to promote the various functions of pulpal cells in vitro and also promote the wound healing process of dentin-pulp complex in vivo from the results of this study. Especially, degraded DMCs induced by MMP20 showed higher healing ability compared to other MMP molecules. To identify the components of the degraded DMCs by MMP20, proteome analysis was performed and eight candidate proteins were acquired from the analysis. From these results, the candidate molecules had possibilities to promote pulpal repair process and development of true biological pulp capping agent might be possible in the near future.
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Report
(4 results)
Research Products
(14 results)
