The development of a new dental adhesive restoration to reduce dentin endogenous matrix metalloproteinases activity.

• Project/Area Number: 25462959
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Conservative dentistry
• Research Institution: Kagoshima University (2015); Okayama University (2013-2014)
• Principal Investigator: Nishitani Yoshihiro 鹿児島大学, 医歯学域歯学系, 教授 (60325123)
• Co-Investigator(Kenkyū-buntansha): YOSHIYAMA Masahiro 岡山大学, 大学院医歯薬学総合研究科, 教授 (10201071)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 接着歯学 / 象牙質 / マトリックスメタロプロテアーゼ / レジン

Outline of Final Research Achievements

For the purpose of establishing a dental adhesive methods to reduce the re-treatment after the resin composite treatment, without lowering the adhesive performance, it was examined a new adhesive system to reduce the dentin MMPs activity. As a result, the possibility of achieving the purpose by adding diethylene triamine pentaacetic acid is a crosslinking agent that can be applied clinically.

Research Products

• [Journal Article] Mineralization of Resin Using Experimental Adhesives Containing Hydroxyapatite in Long Term (2015)
  • Author(s): Tomohiro HOSHIKA, Yoshihiro NISHITANI, Kei TAKAHASHI, Haruka OGATA, Naoko OHARA, Takehiro KAJIHARA, Masahiro YOSHIYAMA
  • Journal Title: Journal of Oral Tissue Engineering Volume: 13(2) Pages: 85-95
  • NAID: 130005150543
  • Peer Reviewed
• [Journal Article] Effects of quaternary ammonium-methacrylates on the mechanical properties of unfilled resins. (2014)
  • Author(s): Hoshika T, Nishitani Y, Yoshiyama M, Key WO 3rd, Brantley W, Agee KA, Breschi L, Cadenaro M, Tay FR, Rueggeberg F, Pashley DH.
  • Journal Title: Dental Materials Volume: 30 Issue: 11 Pages: 1213-1223
  • DOI: 10.1016/j.dental.2014.08.365
  • Peer Reviewed / Open Access
• [Journal Article] Effects of chlorhexidine in self-etching adhesive: 24 hours results (2013)
  • Author(s): Nishitani Y, Hosaka K, Hoshika T, Yoshiyama M, Pashley DH.
  • Journal Title: Dental Materials Journal Volume: 32 Issue: 3 Pages: 420-424
  • DOI: 10.4012/dmj.2012-199
  • NAID: 10031158842
  • ISSN: 0287-4547, 1881-1361
  • Peer Reviewed