Clarification of mechanisms underlying ectopic persistent pain to establish proper diagnosis and treatment assosiated with endodontic disease
| Project/Area Number |
25462968
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Conservative dentistry
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| Research Institution | Nihon University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SHINODA Masamichi 日本大学, 歯学部, 准教授 (20362238)
HONDA Kuniya 日本大学, 歯学部, ポスト・ドクトラル・フェロー (20548945)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 関連痛 / referred pain / 異所性疼痛 / ectopic tooth pain / 歯痛 / 非歯原性歯痛 / 痛覚過敏 / 歯痛錯誤 / Orofacial pain / 歯髄炎 / 根尖性歯周炎 / 異常感覚 / 歯原性歯痛 / 異常疼痛 / pERK / TLR4 |
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| Outline of Final Research Achievements |
It is well known that the referred pain and non odontogenic toothache is frequently misdiagnosed as odontogenic toothache by dentists, and lead clinicians mistreated to irreversible dental procedures. Thus, clarification of the mechanism for the non odontogenic toothache is important.
In the present study, our results indicated that phosphorylation of extracellular signal-regulated protein kinase in the trigeminal transition zone and laminated subnucleus caudalis has an important role for the pulpitis- or periapical periodontitis-indeced masseter hyperalgesia. Futhermore, we also clarify that TLR4-Hsp70 signaling in trigeminal ganglion neurons contributes tongue-referred pain associated with tooth pulp inflammation.
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Report
(4 results)
Research Products
(13 results)
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[Journal Article] Involvement of trigeminal transition zone and laminated subnucleus caudalis in masseter muscle hypersensitivity associated with tooth inflammation.2014
Author(s)
Shimizu K, Matsumoto K, Noma N, Matsuura S, Ohara K, Komiya H, Watase T, Ogiso B, Tsuboi Y, Shinoda M, Hatori K, Nakaya Y, Iwata K.
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Journal Title
PLoS OＮＥ
Volume: 9(10)
Issue: 10
Pages: e109168-e109168
DOI
Related Report
Peer Reviewed / Open Access
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