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Clarification of mechanisms underlying ectopic persistent pain to establish proper diagnosis and treatment assosiated with endodontic disease

Research Project

Project/Area Number 25462968
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Conservative dentistry
Research InstitutionNihon University

Principal Investigator

SHIMIZU Kohei  日本大学, 歯学部, 助教 (10508609)

Co-Investigator(Kenkyū-buntansha) SHINODA Masamichi  日本大学, 歯学部, 准教授 (20362238)
HONDA Kuniya  日本大学, 歯学部, ポスト・ドクトラル・フェロー (20548945)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords関連痛 / referred pain / 異所性疼痛 / ectopic tooth pain / 歯痛 / 非歯原性歯痛 / 痛覚過敏 / 歯痛錯誤 / Orofacial pain / 歯髄炎 / 根尖性歯周炎 / 異常感覚 / 歯原性歯痛 / 異常疼痛 / pERK / TLR4
Outline of Final Research Achievements

It is well known that the referred pain and non odontogenic toothache is frequently misdiagnosed as odontogenic toothache by dentists, and lead clinicians mistreated to irreversible dental procedures. Thus, clarification of the mechanism for the non odontogenic toothache is important.
In the present study, our results indicated that phosphorylation of extracellular signal-regulated protein kinase in the trigeminal transition zone and laminated subnucleus caudalis has an important role for the pulpitis- or periapical periodontitis-indeced masseter hyperalgesia. Futhermore, we also clarify that TLR4-Hsp70 signaling in trigeminal ganglion neurons contributes tongue-referred pain associated with tooth pulp inflammation.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (13 results)

All 2016 2015 2014 2013 Other

All Journal Article (3 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (7 results) Book (1 results) Remarks (2 results)

  • [Journal Article] 歯内療法における打診痛を考察する2016

    • Author(s)
      清水康平、羽鳥啓介、大原絹代、篠田雅路、小木曾文内
    • Journal Title

      日本歯科評論

      Volume: 76 Pages: 47-58

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Involvement of trigeminal transition zone and laminated subnucleus caudalis in masseter muscle hypersensitivity associated with tooth inflammation.2014

    • Author(s)
      Shimizu K, Matsumoto K, Noma N, Matsuura S, Ohara K, Komiya H, Watase T, Ogiso B, Tsuboi Y, Shinoda M, Hatori K, Nakaya Y, Iwata K.
    • Journal Title

      PLoS ONE

      Volume: 9(10) Issue: 10 Pages: e109168-e109168

    • DOI

      10.1371/journal.pone.0109168

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Toll-like receptor 4 signaling in trigeminal ganglion neurons contributes tongue-referred pain associated with tooth pulp inflammation2013

    • Author(s)
      Kinuyo Ohara, *Kohei Shimizu, Shingo Matsuura, Bunnai Ogiso, Daisuke Omagari, Masatake Asano, Yoshiyuki Tsuboi, Masamichi Shinoda and Koichi Iwata
    • Journal Title

      Journal of Neuroinflammation

      Volume: 10 Issue: 1 Pages: 139-139

    • DOI

      10.1186/1742-2094-10-139

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 急性歯髄炎により誘導される歯痛錯誤の末梢神経機構2015

    • Author(s)
      古宮 宏記、清水 康平、林 誠、鶴町 保、小木曾 文内
    • Organizer
      第143回 日本歯科保存学会秋季学術大会
    • Place of Presentation
      文京シビックセンター(東京都文京区)
    • Year and Date
      2015-11-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] 咬筋痛に誘導される歯髄痛覚過敏発症の神経機構解明2014

    • Author(s)
      渡瀬 哲郎、清水康平、鶴町保、上原輝映、小木曾文内
    • Organizer
      第141 回日本歯科保存学会2014 年度秋季学術大会
    • Place of Presentation
      山形テルサ(山形県山形市)
    • Year and Date
      2014-10-31
    • Related Report
      2014 Research-status Report
  • [Presentation] 歯髄の炎症はToll-like Receptor4の働きを介して舌の異常疼痛を誘導する2014

    • Author(s)
      大原 絹代、清水 康平、井比 陽奈、林 誠、小木曽 文内
    • Organizer
      第141 回日本歯科保存学会2014 年度秋季学術大会
    • Place of Presentation
      山形テルサ(山形県山形市)
    • Year and Date
      2014-10-31
    • Related Report
      2014 Research-status Report
  • [Presentation] 咬筋痛に随伴する歯髄痛覚過敏へのGlia細胞の関与2014

    • Author(s)
      渡瀬哲郎、清水康平、篠田雅路、岩田幸一
    • Organizer
      第8回三叉神経領域の感覚-運動統合機構研究会
    • Place of Presentation
      軽井沢研修所(長野県北佐久郡)
    • Year and Date
      2014-10-18
    • Related Report
      2014 Research-status Report
  • [Presentation] CFA誘導性歯髄炎により発症する舌痛覚過敏に対するToll-likeReceptor4 の関与2013

    • Author(s)
      大原 絹代,清水 康平,勝呂 尚,武市 収,平 亜希子,鶴町 保,小木曾 文内
    • Organizer
      日本歯科保存学会2013年度春季学術大会(138回)
    • Place of Presentation
      福岡国際会議場(福岡)
    • Related Report
      2013 Research-status Report
  • [Presentation] CFA誘導性歯髄炎により発症 する舌痛覚過敏に対するToll-like Receptor 4の関与2013

    • Author(s)
      大原 絹代,清水 康平,小木曾 文内,篠田 雅路,岩田 幸一
    • Organizer
      第8回日本大学先端バイオフォーラム学術大会
    • Place of Presentation
      日本大学会館(東京)
    • Related Report
      2013 Research-status Report
  • [Presentation] 歯髄の炎症はToll-like Receptor 4の働きを介して舌の異常疼痛を誘導する2013

    • Author(s)
      大原 絹代,清水 康平,篠田 雅路,岩田 幸一
    • Organizer
      第7回 三叉神経領域の感覚-運動統合機構研究会
    • Place of Presentation
      日本歯科大学新潟生命歯学部・新潟大学駅南キャンパスときめいと(新潟)
    • Related Report
      2013 Research-status Report
  • [Book] メカニズムから読み解く 痛みの臨床テキスト2015

    • Author(s)
      編集:小川 節郎 執筆者:川真田 樹人、牛田 享宏、三枝 里江、齋藤 繁、住谷 昌彦、緒方 徹、細井 昌子、細川 豊史、布施谷 仁志、川股 知之、伊藤 美保、益田 律子、高橋 淳、北原 雅樹、小山 なつ、等 誠司、清水 康平、野間 昇、今村 佳樹 他
    • Total Pages
      254
    • Publisher
      南江堂
    • Related Report
      2014 Research-status Report
  • [Remarks] 日本大学歯学部生理学講座

    • URL

      http://www.dent.nihon-u.ac.jp/phisio/gs_top.html

    • Related Report
      2013 Research-status Report
  • [Remarks] 日本大学歯学部保存学第II講座

    • URL

      http://www.dent.nihon-u.ac.jp/endo/sd_top.html

    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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