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Fabrication of growth factor-sustained release scaffold for treating root apical lesion of root incomplete teeth

Research Project

Project/Area Number 25462977
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Conservative dentistry
Research InstitutionOsaka Dental University

Principal Investigator

SHIDA Muneyasu  大阪歯科大学, 歯学部, 講師 (10187354)

Co-Investigator(Kenkyū-buntansha) 橋本 典也  大阪歯科大学, 歯学部, 准教授 (20228430)
馬場 俊輔  大阪歯科大学, 歯学部, 教授 (40275227)
岡田 正弘  岡山大学, 医歯薬学総合研究科, 准教授 (70416220)
Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords成長因子担持-徐放性足場材料 / ナノ粒子集合体/bFGF複合体 / タンパク質担持-徐放性足場 / タンパク担持 / 徐放性足場材料 / 低結晶性アパタイト / マイクロ粒子 / タンパク質担持
Outline of Final Research Achievements

HAp nanoparticle-assembled powder was applied to exposed dental pulp of rat molars, and the tissue reaction was then examined histologically to assess its biocompatibility and ability to promote hard tissue formation. The pulps of maxillary first molars of male Wistar rats were exposed and then capped directly by using either basic fibroblast growth factors (bFGF)/HAp nanoparticle-assembled powders (experimental group) or only HAp nanoparticle-assembled powders . Histologic examinations showed that there were few inflammatory cells in the pulp near the exposed sites in both groups at 1 week. At 2 weeks, reparative dentin covered with a layer of odontoblast-like cells was observed in the experimental group. bFGF/HAp nanoparticle-assembled powder promoted healing of the dental pulp.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (4 results)

All 2017 2014 Other

All Presentation (3 results) Book (1 results)

  • [Presentation] ナノポーラスアパタイトの孔径によるタンパク質放出挙動の制御2014

    • Author(s)
      岡田正弘, 橋本典也, 馬場俊輔, 至田宗泰, 松本卓也
    • Organizer
      第36回日本バイオマテリアル学会大会
    • Place of Presentation
      タワーホール船堀(東京)
    • Year and Date
      2014-11-18
    • Related Report
      2014 Research-status Report
  • [Presentation] リン酸カルシウム系骨補填材の骨形性能向上を目指した増殖因子捕捉技術の開発

    • Author(s)
      徳田知子,本田義知,橋本典也,上村直也,柿木佐知朗,山岡哲二,馬場俊輔,松本尚之.
    • Organizer
      第8回ナノバイオメディカル学会
    • Place of Presentation
      グランビア和歌山
    • Related Report
      2013 Research-status Report
  • [Presentation] 骨組織再生をめざした増殖因子捕捉技術の開発

    • Author(s)
      徳田知子,本田義知,橋本典也,上村直也,柿木佐知朗,山岡哲二,馬場俊輔,松本尚之.
    • Organizer
      第13回日本再生医療学会総会
    • Place of Presentation
      京都国際会議場
    • Related Report
      2013 Research-status Report
  • [Book] 医療用バイオマテリアルの研究開発2017

    • Author(s)
      青柳隆夫、中岡竜介、迫田秀行、植松美幸、宮島敦子、野村祐介、蓜島由二、伊佐間和郎、岩崎清隆、梅津光生、田中賢、蟹江慧、成田裕司、加藤竜司、石原一彦、馬場俊輔、橋本典也、笠原真二郎、築谷朋典、伊藤恵利
    • Total Pages
      258
    • Publisher
      シーエムシー出版
    • Related Report
      2016 Annual Research Report

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Published: 2014-07-25   Modified: 2019-07-29  

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