Development of new denture dentifrice with Tea tree oil

• Project/Area Number: 25463009
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Prosthodontics/ Dental materials science and
• Research Institution: Nagasaki University
• Principal Investigator: YAMASHITA Rika 長崎大学, 病院(歯学系), 助教 (50336179)
• Co-Investigator(Kenkyū-buntansha): KUROGI Tadafumi 長崎大学, 病院(歯学系), 助教 (70404225) ; EGOSHI Takafumi 長崎大学, 医歯薬学総合研究科(歯学系), 助教 (70706150)
• Research Collaborator: KOSEKI Yusaku
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 精油 / Candida albicans / ティートゥリーオイル / レモングラス / 磨耗試験 / Tea tree oil / C. albicans / Lemongrass / C.albicans

Outline of Final Research Achievements

Essential oils are known for their antifungal activities and efficacy in the treatment of oral candidiasis. This study evaluated whether the essential oils could be used to denture cleaning. Tea tree oil (1.0%) and lemon grass (0.5%, 1.0%) produced significantly higher results than water in the effect of removing biofilms adhering to denture base resin. The surface roughness of specimens after brushing with these essential oils was significantly lower than that of those after brushing with water. It was suggested that these essential oils would be desirable and useful to use for denture cleaning.

Research Products

• [Presentation] 植物精油によるC.albicansの除去効果とレジン表面への影響 (2016)
  • Author(s): 小関優作, 田中利佳, 村田比呂司
  • Organizer: 補綴若手研究会
  • Place of Presentation: KKR 鎌倉わかみや（神奈川県・鎌倉市）
  • Year and Date: 2016-02-27
• [Presentation] 植物精油のレジンに付着したCandida albicansへの影響について (2016)
  • Author(s): 小関優作, 田中利佳,佐藤 薪,大島朋子, 前田伸子, 村田比呂司
  • Organizer: 第８回日本義歯ケア学会学術大会
  • Place of Presentation: 東北大学大学院歯学研究科（宮城県・仙台市）
  • Year and Date: 2016-01-24
• [Presentation] レジンに付着したCandida albicansに対する植物精油の除去効果について (2015)
  • Author(s): 小関優作, 田中利佳, 佐藤 薪, 大島朋子, 前田伸子, 浪越建男, 村田比呂司
  • Organizer: 日本補綴歯科学会九州支部学術大会
  • Place of Presentation: 九州歯科大学講堂（福岡県・北九州市）
  • Year and Date: 2015-08-22