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Investigation of PPAR-gamma antagonists as antiOSA drug.

Research Project

Project/Area Number 25463035
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Prosthodontics/ Dental materials science and
Research InstitutionTsurumi University

Principal Investigator

Iida Ryohei  鶴見大学, 歯学部, 助教 (70339810)

Co-Investigator(Kenkyū-buntansha) Ogawa Takumi  鶴見大学, 歯学部, 教授 (20267537)
Ando Hitoshi  鶴見大学, 歯学部, 講師 (00282765)
山根 明  鶴見大学, 歯学部, 教授 (20166763)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywordsクレンブテロール / PPARγ / IGF-1 / PPAR / 睡眠時無呼吸症 / アンタゴニスト / ラット / 咬筋 / 筋繊維直径 / NADH-TR染色
Outline of Final Research Achievements

The aim of this study was HX531 or clenbuterol could be the drug for obstructive sleep apnea (OSA). Growth of the minimum diameter of masseter muscle fibers was stopped within 2 weeks in rats gave an antagonist of PPARγ, clenbuterol, although that increased until 3 weeks in control. Body weight was kept increased in both of rats, This result suggests clenbuterol may have the ability as the antiOSA drug. Our next focus was the mechanism how diameter of masseter reduced by clenbuterol. We investigated miogenic factors such as MyoD, myogenin, MCK, myostatin and IGF-1. Among them, expression of IGF-1 mRNA was markedly increased in masseter of rats with clenbuterol for 2 weeks. This result indicates that IGF-1 may have a role for repressing the growth of masseter, not gastrocnemius muscle.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (4 results)

All 2016 2015 2013

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Acknowledgement Compliant: 1 results)

  • [Journal Article] MyoD is Regulated by the miR-29a-Tet1 Pathway in C2C12 Myoblast Cells2016

    • Author(s)
      Chikenji A, Ando H, Nariyama M, Suga T, Iida R, Gomi K
    • Journal Title

      Journal of Oral Science

      Volume: 58

    • NAID

      130005158882

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Functions of miR-1 and miR-133a during the postnatal development of masseter and gastrocnemius muscles.2015

    • Author(s)
      Nariyama M, Mori M, Shimazaki E, Ando H, Ohnuki Y, Abo T, Yamane A, Asada Y
    • Journal Title

      Mol Cell Biochem

      Volume: 404 Issue: 1-2 Pages: 17-27

    • DOI

      10.1007/s11010-015-2450-y

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Role of occlusion in mouse masseter muscle acetylcholine receptor clustering2013

    • Author(s)
      MORI, M., NARIYAMA, M., ABO, T., HIRAI, S., OGAWA, T., HAMADA, Y., YAMANE, A. and ASADA, Y.
    • Journal Title

      J. Dent. Res.

      Volume: 92 Issue: 4 Pages: 352-357

    • DOI

      10.1177/0022034513476038

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Age-related changes in rat genioglossus, geniohyoid, and masseter muscles2013

    • Author(s)
      KANEKO, S., IIDA, R., SUGA, T., MORITO, M. and YAMANE, A.
    • Journal Title

      Gerodontology

      Volume: 未定 Issue: 1 Pages: 56-62

    • DOI

      10.1111/ger.12004

    • Related Report
      2013 Research-status Report
    • Peer Reviewed

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Published: 2014-07-25   Modified: 2019-07-29  

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