Bone regeneration by hypertrophic cartilage cells using iPS cells as cell source
Project/Area Number |
25463041
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Prosthodontics/ Dental materials science and
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Research Institution | Osaka Dental University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
HONDA Yoshitomo 大阪歯科大学, 歯学部, 講師 (90547259)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | iPS細胞 / 骨再生 / 間葉系前駆細胞 / 歯科再生医療 |
Outline of Final Research Achievements |
Mesenchymal stem cells (MSCs) are considered a potential autologous therapy for tissue engineering. The available procedures for MSC retrieval from patients are invasive, and their limited in vitro proliferation restricts their use in the treatment of damaged tissues. Therefore, it is important to establish an alternative and safe source of MSCs. The objective of this study was to demonstrate induced pluripotent stem cell (iPSC) generation from a combination of an accessible source tissue and an integration-free method; we also attempted the differentiation of iPSCs into MSC-like cells (MSLCs) for future autologous tissue engineering.
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Report
(4 results)
Research Products
(13 results)
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[Presentation] エピソーマルベクターを用いたヒト歯肉組織由来iPS細胞の樹立2014
Author(s)
梅崎 泰之, 山本 貴子, 西下 直希, 川真田 伸, 本田 義知, 橋本 典也, 柏木 隆宏, 寺内 理恵, 上村 直也, 新井 是宣, 馬場 俊輔, 川添 堯彬
Organizer
第12回 日本再生歯科医学会総会・学術大会
Place of Presentation
徳島大学、徳島市
Year and Date
2014-08-26
Related Report
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[Presentation] Glis1を用いた口腔粘膜由来繊維芽細胞からのiPS細胞樹立の可能性2014
Author(s)
柏木 隆宏, 山本 貴子, 西下 直希, 川真田 伸, 本田 義知, 橋本 典也, 梅崎 泰之, 寺内 理恵, 上村 直也, 新井 是宣, 馬場 俊輔, 川添 堯彬
Organizer
第12回 日本再生歯科医学会総会・学術大会
Place of Presentation
徳島大学、徳島市
Year and Date
2014-08-26
Related Report
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