| Project/Area Number |
25463050
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KUBOKI TAKUO 岡山大学, 大学院医歯薬学総合研究科, 教授 (00225195)
SONOYAMA WATARU 岡山大学, 岡山大学病院, 講師 (40325121)
ONO MITSUAKI 岡山大学, 大学院医歯薬学総合研究科, 助教 (60613156)
AKIYAMA KENTARO 岡山大学, 岡山大学病院, 講師 (70423291)
SHINKAWA SHIGEHIKO 岡山大学, 岡山大学病院, 医員 (10727465)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 骨形成 / BMP-2 / 骨髄 / 口腔インプラント / オッセオインテグレーション / rhBMP-2 / 骨吸収 |
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| Outline of Final Research Achievements |
Recombinant human BMP-2 (rhBMP-2) has been widely used to treat bone defects or bone-associated diseases in human. However, recently our research group found that rhBMP-2 inhibited bone formation in in the bone marrow space. The purpose of this research was to elucidate the mechanism of environmental selective bone induction/suppression of BMP-2. In the mice model, BMP-2 could not induce the bone formation in the bone marrow rich environment. Moreover, large animal model experiments revealed that rhBMP-2 were suitable for operative procedure in the bone marrow poor environment, such as socket lift and socket preservation.
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