New development of periodontal regenerative therapy using growth factors and orthodontic mechanical stress
| Project/Area Number |
25463052
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Kagoshima University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
BANDOU Kenjiro 明海大学, 歯学部, 講師 (50347093)
YAMAMOTO Yoshitake 鹿児島大学, 医歯学域歯学系, 助教 (50380465)
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| Research Collaborator |
Miron Richard J.
Bosshardt Dieter
Sculean Anton
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 歯周組織再生療法 / 成長因子 / エナメルマトリックスプロテイン / テイッシュエンジニアリング / 矯正治療 / メカニカルストレス / ティッシュエンジニアリング |
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| Outline of Final Research Achievements |
It is reported that enamel matrix protein derivative (EMD) enhances periodontal regeneration and an optimal mechanical stress (MS) has a positive effect on bone healing. One-wall intrabony defects were fabricated in bilateral mandibular premolars in beagle dogs, and the premolars were moved into the defects using orthodontic devices. The present study evaluated the effects of MS, autogenous bone grafting (AG) and EMD on periodontal regeneration in the experimental model. Consequently, tooth movement occurred without any complications and the AG and EMD treatment provided more favorable periodontal regeneration characterized by new attachment in the defects when compared to AG alone. These findings indicate that the MS, AG and EMD treatment may be a new approach in periodontal regenerative therapy.
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] 20 years of Enamel Matrix Derivative: The past, the present and the future.2016
Author(s)
Miron RJ, Sculean A, Cochran DL, Froum S, Zucchelli G, Nemcovsky C, Donos N, Lyngstadaas SP, Deschner J, Dard M, Stavropoulos A, Zhang Y, Trombelli L, Kasaj A, Shirakata Y, Cortellini P, Tonetti M, Rasperini G, Jepsen S, Bosshardt DD.
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Journal Title
J Clin Periodontol
Volume: -
Issue: 8
Pages: 1-57
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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