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New development of periodontal regenerative therapy using growth factors and orthodontic mechanical stress

Research Project

Project/Area Number 25463052
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Dental engineering/Regenerative dentistry
Research InstitutionKagoshima University

Principal Investigator

SHIRAKATA YOSHINORI  鹿児島大学, 医歯学域歯学系, 准教授 (60359982)

Co-Investigator(Kenkyū-buntansha) BANDOU Kenjiro  明海大学, 歯学部, 講師 (50347093)
YAMAMOTO Yoshitake  鹿児島大学, 医歯学域歯学系, 助教 (50380465)
Research Collaborator Miron Richard J.  
Bosshardt Dieter  
Sculean Anton  
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords歯周組織再生療法 / 成長因子 / エナメルマトリックスプロテイン / テイッシュエンジニアリング / 矯正治療 / メカニカルストレス / ティッシュエンジニアリング
Outline of Final Research Achievements

It is reported that enamel matrix protein derivative (EMD) enhances periodontal regeneration and an optimal mechanical stress (MS) has a positive effect on bone healing. One-wall intrabony defects were fabricated in bilateral mandibular premolars in beagle dogs, and the premolars were moved into the defects using orthodontic devices. The present study evaluated the effects of MS, autogenous bone grafting (AG) and EMD on periodontal regeneration in the experimental model. Consequently, tooth movement occurred without any complications and the AG and EMD treatment provided more favorable periodontal regeneration characterized by new attachment in the defects when compared to AG alone. These findings indicate that the MS, AG and EMD treatment may be a new approach in periodontal regenerative therapy.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (25 results)

All 2016 2015 2014 2013 Other

All Int'l Joint Research (1 results) Journal Article (15 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 10 results,  Acknowledgement Compliant: 1 results,  Open Access: 1 results) Presentation (8 results) Remarks (1 results)

  • [Int'l Joint Research] ベルン大学歯学部(スイス)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Bone healing capabilities of recombinant human bone morphogenetic protein-9(rhBMP-9) with a chitosan or collagen carrier in rat calvarial defects.2016

    • Author(s)
      Yukiya Shinohara, Toshiaki Nakamura, Yoshinori Shirakata, Kazuyuki Noguchi.
    • Journal Title

      Dent Mater J

      Volume: -

    • NAID

      130005155194

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Osteoinductive potential of 4 commonly employed bone grafts.2016

    • Author(s)
      Richard J Miron, Qiao Zhang, Anton Sculean, Daniel Buser, Benjamin E. Pippenger, Michel Dard, Yoshinori Shirakata,Fatiha Chandad, Yufeng Zhang.
    • Journal Title

      Clin Oral Investig

      Volume: - Pages: 1-7

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Osteogain improves cell adhesion, proliferation and osteoblast differentiation on a bovine-derived natural bone mineral.2016

    • Author(s)
      Richard J Miron, Masako Fujioka-Kobayashi, Yufeng Zhang, Jordi Caballe-Serrano, Yoshinori Shirakata, Dieter D. Bosshardt, Daniel Buser, Anton Sculean.
    • Journal Title

      Clin Oral Implants Res

      Volume: - Pages: 1-7

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 20 years of Enamel Matrix Derivative: The past, the present and the future.2016

    • Author(s)
      Miron RJ, Sculean A, Cochran DL, Froum S, Zucchelli G, Nemcovsky C, Donos N, Lyngstadaas SP, Deschner J, Dard M, Stavropoulos A, Zhang Y, Trombelli L, Kasaj A, Shirakata Y, Cortellini P, Tonetti M, Rasperini G, Jepsen S, Bosshardt DD.
    • Journal Title

      J Clin Periodontol

      Volume: - Issue: 8 Pages: 1-57

    • DOI

      10.1111/jcpe.12546

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 歯周組織再生療法におけるエナメルマトリックスデリバテイブと骨移植材の併用効果を再考する2016

    • Author(s)
      白方良典、野口和行
    • Journal Title

      日本歯周病学会会誌

      Volume: 58 Pages: 1-15

    • Related Report
      2015 Annual Research Report
  • [Journal Article] In situ tissue engineering approach を応用した歯周組織再生療法の試み2016

    • Author(s)
      白方良典
    • Journal Title

      鹿児島大学歯学部紀要

      Volume: 36 Pages: 41-57

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Healing of localized gingival recessions treated with coronally advanced flap alone or combined with an enamel matrix derivative and a porcine acellular dermal matrix. A preclinical study.2015

    • Author(s)
      Yoshinori Shirakata, Anton Sculean, Shinohara Yukiya, Sena Kotarou, Takeuchi Naoshi, Dieter Bosshardt, Kazuyuki Noguchi.
    • Journal Title

      Clin Oral Investig

      Volume: - Pages: 1-10

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Healing of localized gingival recessions treated with coronally advanced flap alone or combined with either a resorbable collagen matrix or subepithelial connective tissue graft. A preclinical study2015

    • Author(s)
      Anton Sculean, Ilja Mihatovic, Yoshinori Shirakata, Dieter Bosshardt, Frank Schwarz, Iglhaut Gerhard
    • Journal Title

      Clin Oral Investig

      Volume: 19 Issue: 4 Pages: 903-909

    • DOI

      10.1007/s00784-014-1299-x

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 特殊な歯周病の診断と治療2014

    • Author(s)
      野口和行、中村利明、白方良典
    • Journal Title

      日本歯科保存学会誌

      Volume: 57 Pages: 477-483

    • NAID

      130005005968

    • Related Report
      2014 Research-status Report
  • [Journal Article] 骨格性下顎前突症を伴う広汎型重度慢性歯周炎に包括的治療を行った一症例2014

    • Author(s)
      白方良典、山本芳丈、野口和行
    • Journal Title

      日本歯周病学会会誌

      Volume: 56 Pages: 442-450

    • NAID

      130004842592

    • Related Report
      2014 Research-status Report
  • [Journal Article] 「歯周病とは」2014

    • Author(s)
      白方良典 野口和行
    • Journal Title

      月刊糖尿病 第3章

      Volume: 6 Pages: 21-29

    • Related Report
      2014 Research-status Report
  • [Journal Article] An exploratory study on the efficacy of rat dedifferentiated fat cells (rDFATs) with a poly lactic-co-glycolic acid/hydroxylapatite (PLGA/HA) composite for bone formation in a rat calvarial defect model2014

    • Author(s)
      Yoshinori Shirakata, Toshiaki Nakamura, Yukiya Shinohara, Katsuyoshi Taniyama, Kenji Sakoda, Takehiko Yoshimoto, Kazuyuki Noguchi
    • Journal Title

      Journal of Materials Science: Materials in Medicine

      Volume: 25 Issue: 3 Pages: 899-908

    • DOI

      10.1007/s10856-013-5124-x

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Periodontal healing after application of enamel matrix derivative in surgical supra/infrabony periodontal defects in rats with streptozotocin-induced diabetes.2014

    • Author(s)
      Shirakata Y, Eliezer M, Nemcovsky CE, Weinreb M, Dard M, Sculean A, Bosshardt DD, Moses O
    • Journal Title

      J Periodontal Res

      Volume: 49 Issue: 1 Pages: 93-101

    • DOI

      10.1111/jre.12084

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Treatment of soft tissue recessions at titanium implants using a resorbable collagen matrix: a pilot study.2014

    • Author(s)
      Schwarz F, Mihatovic I, Shirakata Y, Becker J, Bosshardt D, Sculean A.
    • Journal Title

      Clin Oral Implants Res

      Volume: 25 Issue: 1 Pages: 110-115

    • DOI

      10.1111/clr.12042

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of EMD in combination with bone swaging and calcium phosphate bone cement on periodontal regeneration in one-wall intrabony defects in dogs.2013

    • Author(s)
      Shirakata Y, Yoshimoto T, Takeuchi N, Taniyama K, Noguchi K.
    • Journal Title

      J Periodontal Res

      Volume: 48 Issue: 5 Pages: 37-43

    • DOI

      10.11607/prd.0989

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 1壁性骨内欠損を伴う動物実験モデルを用いた自家骨移植術と矯正的歯の移動に関する研究2015

    • Author(s)
      山本芳丈, 白方良典, 末廣史雄, 宮脇正一
    • Organizer
      第74回日本歯科矯正学会大会
    • Place of Presentation
      福岡国際会議場・マリンメッセ(福岡県博多市)
    • Year and Date
      2015-11-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] ラット頭蓋骨欠損モデルを用いたrecombinant human bone morphogenetic protein-9/コラーゲン担体の骨形成評価2015

    • Author(s)
      篠原敬哉,中村利明,白方良典, 古江きらら, 野口和行
    • Organizer
      平成27年度日本歯周病学会九州5大学・日本臨床歯周病学会九州支部共催合同研修会
    • Place of Presentation
      アクロス福岡(福岡県博多市)
    • Year and Date
      2015-11-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] New bone formation after application of recombinant human bone morphogenetic protein-9 (rhBMP-9) with chitosan or collagen carrier in rat calvarial defects.2015

    • Author(s)
      Toshiaki Nakamura, Yoshinori Shirakata,Yukiya shinohara, Kazuyuki Noguchi
    • Organizer
      Europerio 8
    • Place of Presentation
      UK (London)
    • Year and Date
      2015-06-03 – 2015-06-06
    • Related Report
      2014 Research-status Report
  • [Presentation] The effects of enamel matrix derivative with porcine acellular dermal matrix in the treatment of gingival recession defects. A comparative experimental study in dogs.2015

    • Author(s)
      oshinori Shirakata, Yukiya Shinohara, Kotaro Sena, Naoshi Takeuchi, D. D. Bosshardt, Anton Sculean, Kazuyuki Noguchi
    • Organizer
      Europerio 8
    • Place of Presentation
      UK(London)
    • Year and Date
      2015-06-03 – 2015-06-06
    • Related Report
      2014 Research-status Report
  • [Presentation] ラット頭蓋骨欠損におけるrecombinant human bone morphogenetic protein-9の骨形成効果2015

    • Author(s)
      篠原敬哉,中村利明,白方良典, 野口和行
    • Organizer
      第58回春季日本歯周病学会学術大会
    • Place of Presentation
      千葉(幕張)
    • Year and Date
      2015-05-15 – 2015-05-16
    • Related Report
      2014 Research-status Report
  • [Presentation] An exploratory study on the efficacy of rat dedifferentiated fat cells (rDFATs) with poly lactic-co-glycolic acid/hydroxylapatite (PLGA/HA) composite for bone formation in a rat calvarial defect model2013

    • Author(s)
      Yoshinori Shirakata; Yukiya Shinohara, Katsuyoshi Taniyama,, Toshiaki Nakamura, Kenji Sakoda, , Takehiko Yoshimoto, Kazuyuki Noguchi
    • Organizer
      10th Asian Pacific Society of Periodontology Meeting
    • Place of Presentation
      奈良
    • Related Report
      2013 Research-status Report
  • [Presentation] 骨格性下顎前突症を伴う広汎型重度慢性歯周炎患者に包括的治療を行った一症例

    • Author(s)
      白方良典 山本芳丈 野口和行
    • Organizer
      第56回秋季日本歯周病学会学術大会
    • Place of Presentation
      前橋
    • Related Report
      2013 Research-status Report
  • [Presentation] 脱分化脂肪細胞(DFAT)と乳酸・グリコール酸共重合体/ハイドロキシアパタイトコンポジットを用いたラット頭蓋骨欠損における骨再生fat cells (rDFATs) with poly lactic-co-glycolic acid/hydroxylapatite (PLGA/HA) composite for bone formation in a rat calvarial defect model

    • Author(s)
      中村利明 白方良典 篠原敬哉 谷山勝義、迫田賢二、吉元剛彦、野口和行
    • Organizer
      第56回秋季日本歯周病学会学術大会
    • Place of Presentation
      前橋
    • Related Report
      2013 Research-status Report
  • [Remarks] 鹿児島大学 研究者総覧

    • URL

      http://kuris.cc.kagoshima-u.ac.jp/407943.html

    • Related Report
      2015 Annual Research Report 2014 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2022-02-01  

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