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Development of a biodegradable material with controlled release of growth factors for jaw reconstruction

Research Project

Project/Area Number 25463054
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Dental engineering/Regenerative dentistry
Research InstitutionTokyo Medical University

Principal Investigator

Abukawa Harutsugi  東京医科大学, 医学部, 助教 (50453717)

Co-Investigator(Kenkyū-buntansha) CHIKAZU Daichi  東京医科大学, 医学部, 教授 (30343122)
Matsuo Akira  東京医科大学, 医学部, 教授 (70229417)
Satomi Takafumi  東京医科大学, 医学部, 准教授 (70276921)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywordsbiodegradable material / PLGA / jaw reconstruction / 顎骨再建 / 骨誘導因子 / 吸収性メッシュプレート / 骨芽細胞 / ドラックデリバリー / 生体吸収性材料
Outline of Final Research Achievements

The purpose of this study was to invent biodegradable bone inductive material for jaw reconstruction.
PLGA was used as a base material and osteogenic supplements were incorporated into PLGA(OS/PLGA). OS/PLGA flagments were immersed in PBS and removed after 24h, 48h, 72h, 96h, 120h, and 144h for analysis. OS were detected untill 144h.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (8 results)

All 2015 2014 2013 Other

All Int'l Joint Research (1 results) Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (5 results) Remarks (1 results)

  • [Int'l Joint Research] Massachusetts General Hospital(米国)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Tissue-Engineered Bone With 3-Dimensionally Printed β-Tricalcium Phosphate and Polycaprolactone Scaffolds and Early Implantation: An In Vivo Pilot Study in a Porcine Mandible Model.2015

    • Author(s)
      Konopnicki S, Sharaf B, Resnick C, Patenaude A, Pogal-Sussman T, Hwang KG, Abukawa H, Troulis MJ.
    • Journal Title

      Journal of Oral & Maxillofacial Surgery

      Volume: 73(5) Issue: 5 Pages: 1016.e1-1016.e11

    • DOI

      10.1016/j.joms.2015.01.021

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] A Randomized Trial To Identify The Most Effective Dose Of Dexathethasone For Bilateral Sagittal Split Osteotomies2015

    • Author(s)
      H. Abukawa, Y. Koga, M. Kono, M. Saito, T. Satomi, D. Chikazu
    • Organizer
      The 22nd edition of the International Conference on Oral and Maxillofacial Surgery
    • Place of Presentation
      Melbourne, Australia
    • Year and Date
      2015-10-27 – 2015-10-30
    • Related Report
      2014 Research-status Report
  • [Presentation] 顎骨再建を目的とした骨形成因子徐放型吸収性材料の開発2015

    • Author(s)
      虻川東嗣, 近津大地
    • Organizer
      日本口腔外科学会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-10-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] 下顎枝矢状分割術でのデキサメタゾンリン酸エステルナトリウムの至適投与量は?2015

    • Author(s)
      虻川東嗣、古賀陽子、 河野通秀、 里見貴史、 近津 大地
    • Organizer
      第25回特定非営利活動法人日本顎変形症学会総会・学術大会
    • Place of Presentation
      東京
    • Year and Date
      2015-06-04 – 2015-06-05
    • Related Report
      2014 Research-status Report
  • [Presentation] 特発性下顎頭吸収患者5例の臨床病態に関する検討 -特に活動性病変と非活動性病変の鑑別について-2014

    • Author(s)
      虻川 東嗣, 松尾 朗, 小泉 敏之, 藤川 考, 河野通秀, 浜田 勇人, 岡本 綾子、里見 貴史, 近津 大地
    • Organizer
      日本顎変形症学会
    • Place of Presentation
      アクロス福岡
    • Related Report
      2013 Research-status Report
  • [Presentation] 外科的顎矯正手術におけるデキサメタゾンリン酸エステルナトリウム(デガドロン注射液)投与効果のランダム化比較試験2013

    • Author(s)
      虻川東嗣
    • Organizer
      東京医科大学医学会総会
    • Place of Presentation
      東京医科大学
    • Related Report
      2013 Research-status Report
  • [Remarks] 東京医科大学口腔外科学分野

    • URL

      http://team.tokyo-med.ac.jp/kouku/

    • Related Report
      2015 Annual Research Report

URL: 

Published: 2014-07-25   Modified: 2022-01-27  

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