The effect of angiogenesis induction on vertical bone augmentation
| Project/Area Number |
25463056
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Nihon University |
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Principal Investigator |
SATO Shuichi 日本大学, 歯学部, 教授 (50225942)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 血管新生 / 骨再生 / 垂直方向 / ラット / 骨増生 / 増殖因子 / 幹細胞 |
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| Outline of Final Research Achievements |
The purpose of these studies were investigated the effect of angiogenesis induction on vertical bone augmentation. First study showed basic fibroblast growth factor(FGF-2) promoted angiogenesis earlier on rat non-critical and critical bone defects.The second study evaluated angiogenesis and bone augmentation with rat calvarila guided bone agumentation (GBA) model using micro-CT.The results showed angiogenesis began at sites from brain arteries and gradually increased at bone marrow penetration to vertical direction. The bone augmentation enhanced angiogenesis in rat calvaria GBA model. The third study investigated effect of platelet-derived growth factor (PDGF) on rat calvarial GBA model. The results showed 0.03% PDGF in collagen sponge and chitosan sponge enhanced vertical bone formation on rat calvarium.
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Report
(4 results)
Research Products
(19 results)
