| Project/Area Number |
25463059
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Matsumoto Dental University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Hiroshi 松本歯科大学, 歯学部, 講師 (00278178)
MAKI Shigeru 松本歯科大学, 歯学部, 教授 (20134942)
SADAOKA Sunao 松本歯科大学, 歯学部, 助教 (80549395)
KAWAHARA Ichiroh 松本歯科大学, 歯学部, 講師 (20319114)
笠原 香 松本歯科大学, 歯学部, 准教授 (20064694)
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| Co-Investigator(Renkei-kenkyūsha) |
UDAGAWA Nobuyuki 松本歯科大学, 歯学部, 教授 (70245801)
KUBOKI Yoshinori 北海道大学, 歯学部, 教授 (00014001)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 骨再生 / 糖尿病 / 骨粗鬆症 / ナノコラーゲン / βTCP / 人工骨 / VEGF / ドラッグデリバリー / アパタイト / 幾何構造 / ハイドロキシアパタイト / コラーゲン / ナノ / 骨芽細胞 / 破骨細胞 / ＡＬＰ / オステオカルシン / ＶＥＧＦ / ナノアパタイト / 骨髄間葉系細胞 / 骨形成因子 / 骨吸収因子 / DDS |
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| Outline of Final Research Achievements |
The purpose of development of the bone regeneration therapy for the aggravated alveoral bone resorption due to diabetes mellitus or the osteoporosis, we used nano-atelocollagen with diabetes mellitus / osteoporosis model animal in DDS-HB37H which had a geometry structure and culture attached the mesenchymal cells which gave target medicine and evaluated blood vessel growth in the bone formation and relations with the collagen. As a result, DDS-HB37H made expression of VEGFmRNA reinforced with osterix and the ALP which were osteo- induction factor. Also, VEGF expression increased in bone formation region, and blood vessel was formed in richness. Therefore, DDS-HB37H is thought effective bone regeneration material for diabetes mellitus and the osteoporotic patients.
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