Development of guided tissue regeneration membrane with the control of nanoscale surface structure
| Project/Area Number |
25463061
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Osaka Dental University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
BABA Shunsuke 大阪歯科大学, 歯学部, 教授 (40275227)
HASHIMOTO Yoshiya 大阪歯科大学, 歯学部, 講師 (20228430)
OKADA Masahiro 岡山大学, 医歯薬学総合研究科, 准教授 (70416220)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | ナノ表面構造制御 / エレクトロスピニング法 / 歯周組織再生 / 細胞遮断膜 / 生体吸収性高分子 / ハイドロキシアパタイト / ナノ粒子 / 表面構造 |
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| Outline of Final Research Achievements |
Biodegradable polymer fibers having micron-sized diameters and nano-sized surface roughness could be successfully fabricated by an electrospinning method under high humidity conditions. In addition, highly-dispersible calcium phosphate nanoparticles could be successfully fabricated by a novel method based on a homogenous solid state reaction.
The combination of α- tricalcium phosphate which is bioactive bioceramics and biodegradable polymer fibers exhibited excellent bone forming ability in a rat calvarial bone defect model.
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Report
(4 results)
Research Products
(8 results)
