Development of guided tissue regeneration membrane with the control of nanoscale surface structure

• Project/Area Number: 25463061
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Dental engineering/Regenerative dentistry
• Research Institution: Osaka Dental University
• Principal Investigator: MATSUMOTO Naoyuki 大阪歯科大学, 歯学部, 教授 (70199884)
• Co-Investigator(Kenkyū-buntansha): BABA Shunsuke 大阪歯科大学, 歯学部, 教授 (40275227) ; HASHIMOTO Yoshiya 大阪歯科大学, 歯学部, 講師 (20228430) ; OKADA Masahiro 岡山大学, 医歯薬学総合研究科, 准教授 (70416220)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: ナノ表面構造制御 / エレクトロスピニング法 / 歯周組織再生 / 細胞遮断膜 / 生体吸収性高分子 / ハイドロキシアパタイト / ナノ粒子 / 表面構造

Outline of Final Research Achievements

Biodegradable polymer fibers having micron-sized diameters and nano-sized surface roughness could be successfully fabricated by an electrospinning method under high humidity conditions. In addition, highly-dispersible calcium phosphate nanoparticles could be successfully fabricated by a novel method based on a homogenous solid state reaction.
The combination of α- tricalcium phosphate which is bioactive bioceramics and biodegradable polymer fibers exhibited excellent bone forming ability in a rat calvarial bone defect model.

Research Products

• [Journal Article] Comparison of the bone forming ability of different sized-alpha tricalcium phosphate granules using a critical size defect model of the mouse calvaria (2015)
  • Author(s): Tokuda T, Honda Y, Hashimoto Y, Matsumoto N
  • Journal Title: Nano Biomed Volume: 7 Pages: 63-71
  • NAID: 130006996626
  • Peer Reviewed
• [Journal Article] Human gingival integration-free iPSCs; a source for MSC-Like cells (2015)
  • Author(s): Umezaki Y, Hashimoto Y, Nishishita N, Kawamata S, Baba S.
  • Journal Title: Int J Mol Sci Volume: 16 Issue: 10 Pages: 13633-13648
  • DOI: 10.3390/ijms161025678
  • Peer Reviewed / Open Access
• [Journal Article] Influence of calcination conditions on dispersibility and phase composition of hydroxyapatite crystals calcined with anti-sintering agents (2014)
  • Author(s): Masahiro Okada, Yuko Omori, Mayuko Awata, Tsubasa Shirai, Naoyuki Matsumoto, Shoji Takeda, Tsutomu Furuzono
  • Journal Title: Journal of Nanoparticle Research Volume: 16 Issue: 7
  • DOI: 10.1007/s11051-014-2469-0
  • Peer Reviewed
• [Journal Article] Fabrication of dispersible calcium phosphate nanocrystals via a modified Pechini method under non-stoichiometric conditions (2014)
  • Author(s): Yuko Omori, Masahiro Okada, Shoji Takeda, Naoyuki Matsumoto
  • Journal Title: Materials Science and Engineering C Volume: 42 Pages: 562-568
  • DOI: 10.1016/j.msec.2014.05.071
  • Peer Reviewed
• [Presentation] マウス頭蓋冠臨界骨欠損モデルを用いた粒径の異なるα型第三リン酸カルシウム顆粒の骨形成能の比較 (2015)
  • Author(s): 德田 知子, 本田 義知, 橋本 典也, 松本 尚之
  • Organizer: 第549回 大阪歯科学会例会
  • Place of Presentation: 大阪歯科大学（枚方市）
  • Year and Date: 2015-12-12
• [Presentation] αリン酸三カルシウムコラーゲンスポンジを用いた骨再生に対するインターフェロンγとゾレドロネートの効果 (2015)
  • Author(s): 李 佩祺, 橋本 典也, 本田 義知, 有馬 良幸, 松本 尚之
  • Organizer: 第549回 大阪歯科学会例会
  • Place of Presentation: 大阪歯科大学（枚方市）
  • Year and Date: 2015-12-12
• [Presentation] 均一固相反応系を利用した焼成ナノアパタイトの合成 (2014)
  • Author(s): 岡田正弘, 大森裕子, 松本尚之, 松本卓也
  • Organizer: 日本歯科理工学会第64回秋期学術講演会
  • Place of Presentation: アステールプラザ（広島県、広島市）
  • Year and Date: 2014-10-05
• [Presentation] 融着防止材を用いて焼成したナノアパタイトの分散性と組成 (2014)
  • Author(s): 大森裕子, 岡田正弘, 松本尚之, 古薗勉
  • Organizer: 第8回ナノ・バイオメディカル学会大会
  • Place of Presentation: 和歌山市