Study for influences of activities of sympathetic nerve for pain, differentiation, function and innervation of the mastocatory muscles

• Project/Area Number: 25463065
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Hokkaido University
• Principal Investigator: SATO Jun 北海道大学, 歯学研究科(研究院), 講師 (60319069)
• Co-Investigator(Kenkyū-buntansha): KITAGAWA Yoshimasa 北海道大学, 歯学研究科(研究院), 教授 (00224957) ; YAMAZAKI Yutaka 北海道大学, 歯学研究科(研究院), 教授 (90250464)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 咀嚼筋 / 交感神経 / 副交感神経 / 口腔顎顔面痛 / 慢性疼痛 / ウサギ / 神経線維 / 家兎 / 口腔額顔面痛

Outline of Final Research Achievements

The number of the patients with refractory and chronic orofacial pain is increasing. Many sources of the pain are originated from muscle pain. Muscle pain gets worse by excessive physical and mental stresses. The aim of this study is to elucidate the relationships between pain of the masticatory muscles and activities of sympathetic nerve using some clinical and experimental studies. Clinical studies indicated that inhibition of the activity of sympathetic nerve by irradiation with soft laser to cervical region may cause the changes of threshold of muscle pain. The degree of the change was more prominent in patients with muscle pain than the healthy controls. Experimental studies using growing rabbits indicated that enzyme histochemical adaptive responses and morphological changes of the masseter masticatory muscles after sympathectomy of superior cervical ganglion were observed.

Research Products

• [Journal Article] Use of FDG-PET to detect a chronic odontogenic infection as a possible source of the brain abscess. (2016)
  • Author(s): 2)Sato J, Kuroshima T, Wada M, Satoh A, Watanabe S, Okamoto S, Shiga T, Tamaki N, Kitagawa Y
  • Journal Title: Odontology Volume: 104 Issue: 2 Pages: 239-243
  • DOI: 10.1007/s10266-015-0218-1
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Differences in sequential posttreatment salivary IL-6 levels between patients with and patients without locoregional recurrences of oral squamous cell carcinoma: Part III of a cohort study. (2015)
  • Author(s): Sato J, Ohuchi M, Wada M, Ohga N, Asaka T, Yoshikawa K, Miyakoshi M, Hata H, Satoh A, Kitagawa Y.
  • Journal Title: Oral Surg Oral Med Oral Pathol Oral Radiol Volume: 120 Issue: 6 Pages: 751-60
  • DOI: 10.1016/j.oooo.2015.08.016
  • Peer Reviewed / Open Access
• [Journal Article] 当科で経験した非定型歯痛の臨床的検討 (2014)
  • Author(s): 和田麻友美、山崎 裕、村井知佳、中村祐介、佐藤 淳、秦 浩信、北川善政
  • Journal Title: 北海道歯学会誌 Volume: 34(2) Pages: 106-113
  • Peer Reviewed
• [Journal Article] Enzyme histochemical adaptive response of the medial pterygoid muscle and two heads of the lateral pterygoid muscle to long-term soft diet feeding in growing rabbits. (2014)
  • Author(s): Kitagawa T, Sato J, Ogasawara T, Nojyo Y, Enomoto S, Sabo K.
  • Journal Title: Odontology Volume: 102 Issue: 2 Pages: 272-278
  • DOI: 10.1007/s10266-013-0127-0
  • Peer Reviewed
• [Journal Article] 当科で経験した非定型歯痛症例の臨床的検討. (2014)
  • Author(s): 和田麻友美、山崎 裕、村井知佳、中村祐介、佐藤 淳、秦 浩信、北川善政
  • Journal Title: 北海道歯学会誌 Volume: 34 (2) Pages: 106-113
  • Peer Reviewed
• [Presentation] 口腔の不随意運動でプチプチ音を発するオ－ラルジスキネジアと思われた1例 (2015)
  • Author(s): 佐藤 淳、柳谷美沙、大内 学、浅香卓哉、大賀則孝、佐藤千晴、北川善政
  • Organizer: 第25回日本口腔内科学会学術大会
  • Place of Presentation: 大阪市大阪大学
  • Year and Date: 2015-09-19
• [Presentation] 上頸神経節切除の動物モデルの確立とウサギの咬筋の組織学的変化 (2015)
  • Author(s): 佐藤 淳、小笠原利行、佐野和生、北川善政
  • Organizer: 第28回日本顎関節学会学術大会
  • Place of Presentation: 名古屋国際会議場（愛知県名古屋市）
  • Year and Date: 2015-07-04 – 2015-07-05
• [Presentation] 上頸神経節切除の動物モデルの確立とウサギの咬筋の組織学的変化 (2015)
  • Author(s): 佐藤 淳、小笠原利行、佐野和生、北川善政
  • Organizer: 第28回日本顎関節学会総会・学術大会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2015-07-04
• [Presentation] 交感神経切除が成長期のウサギの咬筋におよぼす影響について (2014)
  • Author(s): 佐藤 淳、小笠原利行、佐野和生、北川善政
  • Organizer: 第27回日本顎関節学会学術大会
  • Place of Presentation: 九州大学医学部百年講堂（福岡県福岡市）
  • Year and Date: 2014-07-19 – 2014-07-20
• [Presentation] 交感神経切除が成長期のウサギの咬筋におよぼす影響について (2014)
  • Author(s): 佐藤 淳、小笠原利行、佐野和生、北川善政
  • Organizer: 第27回日本顎関節学会総会
  • Place of Presentation: 九州大学医学部百年講堂（福岡市）
• [Presentation] 関節結節削除術を適応した多数の基礎疾患を有する両側習慣性顎関節脱臼の1例 (2013)
  • Author(s): 佐藤 淳、佐藤千晴、北川善政
  • Organizer: 第26回日本顎関節学会総会
  • Place of Presentation: 学術総合センタ－一橋記念講堂（東京）