Pathological condition elucidation of bisphosphonate-related osteonecrosis of the jaw which applied mechanical stress
| Project/Area Number |
25463067
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Akita University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
FUKUDA MASAYUKI 秋田大学, 医学部, 准教授 (20272049)
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| Co-Investigator(Renkei-kenkyūsha) |
NAKATA AKIRA 秋田大学, 医学部, 助教 (50400510)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | ビスフォスフォネート製剤関連顎骨壊死 / ビスフォスフォネート製剤 / 骨芽細胞 / メカニカルストレス / ビスフォスフォネート製材関連顎骨壊死 / ビスフォスフォネート製材 |
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| Outline of Final Research Achievements |
In this study, we clarified that bisphosphonate（BP) raised ALP activity and suppressed expression and production of OPG on osteoblasts, in addition, mechanical compression stress also suppressed expression and production of OPG. Therefore, BP promotes osteoblasts differentiation by a rise of ALP, but it is thought that promote osteoclasts differentiation by fall of OPG. Accordingly, as for BP and the mechanical compression stress to jawbone, what deposition to alveolar bone of BP and jawbone promoted because we were accelerated and acted on bone metabolic turnover in osteoblasts was suggested. When they elucidate one end of a clinical condition formation mechanism of BRONJ, this study results give fundamental knowledge.
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Report
(4 results)
Research Products
(5 results)
