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Pathological condition elucidation of bisphosphonate-related osteonecrosis of the jaw which applied mechanical stress

Research Project

Project/Area Number 25463067
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Surgical dentistry
Research InstitutionAkita University

Principal Investigator

Takano Hiroshi  秋田大学, 医学部, 助教 (30282172)

Co-Investigator(Kenkyū-buntansha) FUKUDA MASAYUKI  秋田大学, 医学部, 准教授 (20272049)
Co-Investigator(Renkei-kenkyūsha) NAKATA AKIRA  秋田大学, 医学部, 助教 (50400510)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsビスフォスフォネート製剤関連顎骨壊死 / ビスフォスフォネート製剤 / 骨芽細胞 / メカニカルストレス / ビスフォスフォネート製材関連顎骨壊死 / ビスフォスフォネート製材
Outline of Final Research Achievements

In this study, we clarified that bisphosphonate(BP) raised ALP activity and suppressed expression and production of OPG on osteoblasts, in addition, mechanical compression stress also suppressed expression and production of OPG. Therefore, BP promotes osteoblasts differentiation by a rise of ALP, but it is thought that promote osteoclasts differentiation by fall of OPG. Accordingly, as for BP and the mechanical compression stress to jawbone, what deposition to alveolar bone of BP and jawbone promoted because we were accelerated and acted on bone metabolic turnover in osteoblasts was suggested. When they elucidate one end of a clinical condition formation mechanism of BRONJ, this study results give fundamental knowledge.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (5 results)

All 2015

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (4 results)

  • [Journal Article] ビスフォスフォネート製剤関連顎骨壊死の病態形成における骨芽細胞へのメカニカルストレスが及ぼす影響2015

    • Author(s)
      髙野裕史、中田 憲、山崎雅人、今野泰典、五十嵐秀光、小澤 諒、福地峰世、桑島精一、福田雅幸
    • Journal Title

      みちのく歯学会雑誌

      Volume: 46 Pages: 31-32

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Presentation] ビスフォスフォネート製剤関連顎骨壊死の病態形成における骨芽細胞へのメカニカルストレスが及ぼす影響2015

    • Author(s)
      髙野裕史,中田 憲,山崎雅人,桑島精一,今野泰典,小澤 諒,福地峰世,福田雅幸
    • Organizer
      第68回東北地区歯科医学会
    • Place of Presentation
      岩手県歯科医師会館
    • Year and Date
      2015-10-31
    • Related Report
      2015 Annual Research Report
  • [Presentation] Zoledronate添加と機械的圧縮ストレス刺激が骨芽細胞へ及ぼす影響について2015

    • Author(s)
      髙野裕史,中田 憲,山崎雅人,桑島精一,今野泰典,小澤 諒,福地峰世,福田雅幸
    • Organizer
      第60回(公社)日本口腔外科学会総会・学術大会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2015-10-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] Zoledronate添加後の骨芽細胞における機械的圧縮ストレス刺激の影響について2015

    • Author(s)
      髙野裕史、中田 憲、山崎雅人、桑島精一、福田雅幸
    • Organizer
      第69回日本口腔科学会学術集会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2015-05-14 – 2015-05-15
    • Related Report
      2014 Research-status Report
  • [Presentation] Zoledronate添加後の骨芽細胞における機械的圧縮ストレス刺激の影響について2015

    • Author(s)
      髙野裕史、中田 憲、山崎雅人、桑島精一、福田雅幸
    • Organizer
      第69回NPO法人日本口腔科学会学術集会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2015-05-13
    • Related Report
      2015 Annual Research Report

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Published: 2014-07-25   Modified: 2019-07-29  

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