| Project/Area Number |
25463069
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Takahiro Abe 東京大学, 医学部附属病院, 特任講師 (20383250)
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| Co-Investigator(Kenkyū-buntansha) |
阿部 雅修 東京大学, 保健・健康推進本部, 講師 (10392333)
小笠原 徹 東京大学, 医学部附属病院, 講師 (20359623)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 口腔癌 / S1P / 口腔がん / スフィンゴ脂質 / 軸索ガイダンス因子 |
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| Outline of Final Research Achievements |
Sphingosine-1-phosphate (S1P) is a metabolized product of the sphingolipid. It acts as an important factor in regulating malignant tumor progression, arteriosclerosis, diabetes, osteoporosis, etc. Therefore, it has attracted a lot of attention in the recent times. S1P is secreted by various cells and acts in an autocrine or paracrine manner as a signaling factor through five specific G protein-coupled receptors, but S1P signal transduction in oral cancer is still not clear. In this study, we examined the influence of S1P on cell proliferation and cell migration by using cell lines of oral squamous cell carcinoma. We obtained some knowledge about S1P-signaling only after confirmation with an expression pattern of the S1P receptor subtype (S1PR1-5) of the cell lines.
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