The analysis of micro RNA in 4NQO-induced rat tongue cancer model

• Project/Area Number: 25463075
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Gifu University
• Principal Investigator: YONEMOTO KAZUHIRO 岐阜大学, 医学部附属病院, 助教 (80422731)
• Co-Investigator(Kenkyū-buntansha): MAKITA HIROKI 岐阜大学, 大学院医学系研究科, 講師 (50345790) ; SHIBATA TOSHIYUKI 岐阜大学, 大学院医学系研究科, 教授 (50226172)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: miRNA / 4NQO舌癌ラットモデル / 4NQO誘発舌癌ラットモデル

Outline of Final Research Achievements

We aim to examine the usefulness of 4-NQO induced rat tongue cancer as human oral carcinogenesis model by analyzing miRNA's which expression abnormality is reported in in human squamous cell carcinoma.
We identified upregulation of mir21 and downregulation of miR-99a and miR-100 like human squamous cell carcinoma in this study,but it was not the significant difference.On the other hand,the expression of miR155 and miR130b was downregulation unlike human squamous cell carcinoma.