| Project/Area Number |
25463080
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
UEDA Minoru 名古屋大学, 医学系研究科, 教授 (00151803)
YAMAMOTO Noriyuki 名古屋大学, 医学部附属病院, 講師 (60378156)
FURUE Hiroki 名古屋大学, 医学部附属病院, 病院助教 (40567012)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 放射線性皮膚炎 / 培養上清 |
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| Outline of Final Research Achievements |
Radiation-induced dermatitis is one of the serious side effects in head and neck cancer treatment.
Recently, serum-free conditioned medium derived from human bone marrow mesenchymal stem cells (MSC-CM) are reported to express a variety of growth factors relation with tissue repair. In this study, we evaluated the efficacy of MSC-CM for the treatment of radiation-induced dermatitis.
To make model of radiation-induced dermatitis, rats were irradiated. And MSC-CM was gave various administration methods (subcutaneous injection, application, intravenous administration) to rats for treatment to radiation-induced dermatitis. However, as for the results, the efficacy of MSC-CM was not clear unlike a hypothesis.
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