Function analysis of TMEM16E using TMEM16E knockout mice
Project/Area Number |
25463085
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Surgical dentistry
|
Research Institution | Hiroshima University |
Principal Investigator |
MIZUTA KUNIKO 広島大学, 医歯薬保健学研究院(歯), 助教 (40432679)
|
Co-Investigator(Kenkyū-buntansha) |
TOBIUME KEI 広島大学, 大学院医歯薬保健学研究院(歯), 准教授 (40350037)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | TMEM16E / ノックアウトマウス / 筋ジストロフィー / GDD / 顎骨骨幹異形成症 |
Outline of Final Research Achievements |
In this study, TMEM16E knockout mice showed no phenotypic signs. The result suggested that the function of TMEM16E was compensated by other muscular dystrophy related molecules. During in vitro human myogenic cell differentiation, TMEM16E protein expression was up-regulated in mitotic myoblasts as well as myotubes. This finding suggests that TMEM16E protein expression is regulated in a cell cycle dependent manner.
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] CD44(high) /ALDH1(high) head and neck squamous cell carcinoma cells exhibit mesenchymal characteristics and GSK3β-dependent cancer stem cell properties.2016
Author(s)
Seino S, Shigeishi H, Hashikata M, Higashikawa K, Tobiume K, Uetsuki R, Ishida Y, Sasaki K, Naruse T, Rahman MZ, Ono S, Simasue H, Ohta K, Sugiyama M, Takechi M.
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Journal Title
J Oral Pathol Med
Volume: 45
Issue: 3
Pages: 180-188
DOI
Related Report
Peer Reviewed / Open Access
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