Development of hybrid biomaterial having drug controlled release control ability

Research Project

Project/Area Number	25463086
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Surgical dentistry
Research Institution	Hiroshima University
Principal Investigator	NINOMIYA YOSHIAKI 広島大学, 大学病院, 助教 (60335685)
Co-Investigator(Kenkyū-buntansha)	TAKECHI Masaaki 広島大学, 医歯薬保健学研究院, 准教授 (00304535) NAKAGAWA Takayuki 広島大学, 大学病院, 病院助教 (30456230) 南正彦広島大学, 大学病院, その他 (90625980)
Project Period (FY)	2013-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000) Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords	顎骨骨髄炎 / 高機能性薬物徐法担体 / 組織学的評価 / 無機材料 / 有機材料 / 高機能性薬物徐放担体 / ハイブリッド材料 / 生体吸収性有機材料 / 生体吸収性無期材料 / インテリジェント
Outline of Final Research Achievements	There is the basic need studying in line with clinical application to shorten a treatment period of the osteomyelitis of jaw.I make a rabbit osteomyelitis of jaw model and perform an antibacterial effect of high functional drug controlled release carrier which incorporated various antimicrobial and histologic evaluations such as bone conduction ability, the osteoplasty ability. Specifically, I examine bone substitution characteristics of high functional drug controlled release carrier which incorporated a histologic evaluation of inflammation, histocompatibility of high functional drug controlled release carrier which incorporated various antimicrobial and bone conduction-related examination, various antimicrobial after having made an osteomyelitis of jaw animal model.