A study of calcium sensing receptors in odontogenic tumors

Research Project

Project/Area Number	25463088
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Surgical dentistry
Research Institution	Kyushu University
Principal Investigator	Kubota Yasutaka 九州大学, 歯学研究院, 共同研究員 (60205151)
Co-Investigator(Kenkyū-buntansha)	梶岡俊一九州大学, 医学研究院, 准教授 (90274472)
Project Period (FY)	2013-04-01 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000) Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords	角化嚢胞性歯原性腫瘍由来線維芽細胞 / カルシウム感受性受容体 / BMP-2 / BMP－２ / 歯原性腫瘍 / 線維芽細胞
Outline of Final Research Achievements	The Fibroblasts isolated from odontogenic tumors express calcium sensing receptors. However, the precise function of the receptors is obscure. In this study, we showed that the expression of BMP-2 gene and protein was enhanced by calcium concentration dependent manner in the fibroblasts. These results may suggest the new methods for the bone formation by calcium which is cheep and safe.

Report

(5 results)