| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Glycogen synthase kinase-3 (GSK-3) is known to be a key enzyme for regulating Wnt signaling pathway which is an important role of bone regeneration. We focused on “lithium”, GSK-3 inhibitor, and attempted to accelerate bone regeneration by local application of lithium. In in vivo experiment using rodents, our results demonstrated that lithium could facilitate bone formation. Subsequently, we evaluated whether lithium application into extraction sites of teeth would be safe and effective on bone healing in a clinical trial. Local application of lithium carbonate did not cause adverse events in the process of bone healing. Serum lithium concentrations also were lower than a detection limit in all research subjects. These result suggested that safety of local lithium application was confirmed. However, further study would be necessary to evaluate an effectiveness of local lithium application for facilitating bone regeneration.
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