Regeneration of hypofunctional salivary gland with the stem-like cell
| Project/Area Number |
25463092
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Fukuoka Dental College (2015)
Kumamoto University (2013-2014) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SHINOHARA MASANORI 熊本大学, 医学部附属病院, その他 (90117127)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 唾液腺 / 再生 / 放射線 / 再生･修復 / 分化 / 機能回復 / 再生・修復 / 発生・分化 / 加齢 |
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| Outline of Final Research Achievements |
We observed submandibular gland of irradiated mouse decreased α-amylase, EGF, EGFR, HGF, c-Met, bFGF and FGFR. The stem-like cell of mouse submandibular gland showed similar findings to them with exposure to radiation. From the results of these experiments, we induced regeneration of the stem-like cell suffered from radiation damage and demonstrated EGF, KGF and type IV collagen play an important role in function recovery.
To clear its mechanism, we require further research.
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Report
(4 results)
Research Products
(5 results)
