| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
Recently, molecular targeted drugs have begun to emerge. They have recently been in use for clinical standard treatment and reportedly have a high therapeutic effect. However, molecular targeted therapy has neither been established for oral squamous cell carcinoma nor has been defined effective target molecules. A research representative has listed 167 target molecule candidates for oral squamous cell carcinoma by getting Omics analysis technology into full use. The present study intended to examine the serviceability and applicability of listed up abnormal molecule expression as a tumor marker and attempt the feasibility of developing into clinical tests after conducting pre-clinical test using animal models. The result of this study revealed that HSP90 and PDE5 have potentials to become good candidates as therapeutic targets for oral squamous cell carcinoma.
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