The development of the specific molecular target drug for oral cancer
| Project/Area Number |
25463098
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Surgical dentistry
|
|---|
| Research Institution | Tokyo Dental College |
|---|
Principal Investigator |
ONDA Takeshi 東京歯科大学, 歯学部, 講師 (30433949)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | 口腔扁平上皮癌 / 分子標的治療 / バイオマーカー / トランスクリプトーム / プロテオミクス / メタボロミクス / HSP90 / PDE5 / 多階層オミックス解析 / Heat shock protein / Phosphodiesterase / 17-AAG / Sildenafil Citrate / 免疫療法 / メタボローム / ＨＳＰ９０ |
|---|
| Outline of Final Research Achievements |
Recently, molecular targeted drugs have begun to emerge. They have recently been in use for clinical standard treatment and reportedly have a high therapeutic effect. However, molecular targeted therapy has neither been established for oral squamous cell carcinoma nor has been defined effective target molecules. A research representative has listed 167 target molecule candidates for oral squamous cell carcinoma by getting Omics analysis technology into full use. The present study intended to examine the serviceability and applicability of listed up abnormal molecule expression as a tumor marker and attempt the feasibility of developing into clinical tests after conducting pre-clinical test using animal models. The result of this study revealed that HSP90 and PDE5 have potentials to become good candidates as therapeutic targets for oral squamous cell carcinoma.
|
Report
(4 results)
Research Products
(46 results)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] 東京歯科大学千葉病院口腔外科における平成26年度初診患者の臨床統計2015
Author(s)
渡邊 豪士, 翁長 欣子, 鬼谷 薫, 金川 結紀子, 小杉 彩歌, 小坂井 絢子, 左 右, 松本 暢久, 有泉 高晴, 山田 祥, 右田 雅士, 恩田 健志, 成田 真人, 藥師寺 孝, 大畠 仁, 高木 多加志, 高野 伸夫, 柴原 孝彦
Organizer
第300回東京歯科大学記念学会・総会
Place of Presentation
東京都千代田区
Year and Date
2015-10-17
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
