Analysis of inflammatory network and molecularly-targeted therapy in tempromandibular joint inflammation
| Project/Area Number |
25463099
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Nihon University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OGURA Naomi 日本大学, 松戸歯学部, 講師 (10152448)
ITO Ko 日本大学, 松戸歯学部, 講師 (20419758)
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| Research Collaborator |
AKUTSU Miwa 日本大学, 松戸歯学部, 助教 (10523524)
KAWASHIMA Mutsumi 日本大学, 松戸歯学部, 助手(専任扱)
HATTORI Toshio 日本大学, 松戸歯学部, 大学院生
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 顎関節 / 滑膜炎 / 顎関節滑膜細胞 / 網羅的遺伝子発現解析 / シグナリング・パスウェイ解析 / 消炎鎮痛薬 / 阻害剤 / 炎症性サイトカイン / IL-1β / TNF-α / IL-1β+TNF-α共刺激 / MAPK / NFκB / 顎関節内障 / interleukin-17 / interleukin-6 / CCL20 / 炎症 / 非ステロイド系消炎鎮痛薬 / interleukin-1β / prostaglandin E2 |
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| Outline of Final Research Achievements |
Synovitis, an inflammatory disorder of the synovial membrane, frequently accompanies internal derangement and/or osteoarthritis in temporomandibular joint (TMJ) and has been suggested to be a key feature of intracapsular pathological conditions of TMJ. To identify inflammatory factors and signaling pathways associated with synovitis, we investigated the gene expression profiles and the signaling pathway analysis in TMJ synovial fibroblasts treated with inflammatory cytokines. Signaling pathway analysis indicated that the expressions of inflammatory factors were stimulated by NFκB and PAMK. Next, we investigated the effects of inhibitors of cyclooxygenase, NFκB, and PAMK. The expressions of inflammatory factors were decreased in synovial fibroblasts treated by those inhibitors. The approach used in this study may be useful for revealing the inflammatory networks and the effect of the anti-inflammatory drugs in the synovitis of the TMJ.
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Report
(4 results)
Research Products
(21 results)
