| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Nucleus accumbens (NAc) is one of the terminal areas of mesolimbic dopaminergic neurons that project from the ventral tegmental area. NAc contains cholinergic neurons and animal experiments have shown that selective depletion of these neurons impairs cognitive function, including memory. Opioids are applied to control persistent pain and amnesia is a recognised adverse effect. There are three subtypes of opioid receptors: mu, delta and kappa. Accumbal cholinergic neurons express delta and mu receptors that are thought to exert inhibition of cholinergic activity. In the present study, we analysed the roles of delta and mu receptors in the regulation of accumbal acetylcholine efflux of freely moving rats by using in vivo microdialysis. We also studied the noradrenaline-dopamine interaction in the nucleus accumbens.
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