| Project/Area Number |
25463102
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Tsurumi University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SATOMURA Kazuhito 鶴見大学, 歯学部, 教授 (80243715)
TATEHARA Seiko 鶴見大学, 歯学部, 講師 (90380089)
TOKUYAMA Reiko 鶴見大学, 歯学部, 助教 (20380090)
IDE Shinji 鶴見大学, 歯学部, 助教 (00611998)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 口腔カンジダ症 / 光線力学療法 / 405nmレーザー光 / 超高齢社会 / レーザー光 / 治療法・予防法 |
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| Outline of Final Research Achievements |
Although oral candidiasis, an opportunistic infection caused by Candida species, has been conventionally treated by topical and/or systemic administration of antifungal agents, this mediation therapy is prone to raise the drug resistance of Candida species as well as multiple side effects. Therefore, it is important to establish a minimally invasive therapeutic strategy and prophylactic approach for oral candidiasis. Here, we focused on photodynamic therapy with 405-nm blue light, and examined the effect of 405-nm blue light irradiation on the growth of Candida albicans (C. albicans).
Results: Irradiations at 200 mW of the output for 10 and 20 minuets showed about 55 % and 90 % significant growth inhibition, respectively. C. albicans growth was suppressed by 405-nm blue light irradiation, suggesting that 405-nm blue light irradiation is a promising means for treatment and prevention of oral candidiasis.
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