Possible application of 405-nm blue light irradiation for the treatment and the prevention of oral candidiasis

• Project/Area Number: 25463102
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Tsurumi University
• Principal Investigator: YAMACHIKA Shigeo 鶴見大学, 歯学部, 講師 (60182565)
• Co-Investigator(Kenkyū-buntansha): SATOMURA Kazuhito 鶴見大学, 歯学部, 教授 (80243715) ; TATEHARA Seiko 鶴見大学, 歯学部, 講師 (90380089) ; TOKUYAMA Reiko 鶴見大学, 歯学部, 助教 (20380090) ; IDE Shinji 鶴見大学, 歯学部, 助教 (00611998)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 口腔カンジダ症 / 光線力学療法 / 405nmレーザー光 / 超高齢社会 / レーザー光 / 治療法・予防法

Outline of Final Research Achievements

Although oral candidiasis, an opportunistic infection caused by Candida species, has been conventionally treated by topical and/or systemic administration of antifungal agents, this mediation therapy is prone to raise the drug resistance of Candida species as well as multiple side effects. Therefore, it is important to establish a minimally invasive therapeutic strategy and prophylactic approach for oral candidiasis. Here, we focused on photodynamic therapy with 405-nm blue light, and examined the effect of 405-nm blue light irradiation on the growth of Candida albicans (C. albicans).
Results: Irradiations at 200 mW of the output for 10 and 20 minuets showed about 55 % and 90 % significant growth inhibition, respectively. C. albicans growth was suppressed by 405-nm blue light irradiation, suggesting that 405-nm blue light irradiation is a promising means for treatment and prevention of oral candidiasis.

Research Products

• [Journal Article] Antibacterial and antifungal effect of 405-nm monochromatic laser on endodontopathogenic microorganisms (2014)
  • Author(s): Takahiro Imamura, Seiko Tatehara, Yusuke Takebe, Reiko Tokuyama, Tomoko Ohshima, Nobuko Maeda, Kazuhito Satomura
  • Journal Title: International Journal of Photoenergy Volume: Volume 2014 Pages: 1-7
  • DOI: 10.1155/2014/387215
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] 5-アミノレブリン酸を用いた新たな難治性感染根管治療の可能性 (2015)
  • Author(s): 今村武浩, 大島朋子, 前田伸子, 里村一人
  • Organizer: 日本歯科薬物療法学会
  • Place of Presentation: 鶴見大学（神奈川県横浜市）
  • Year and Date: 2015-06-20
• [Presentation] 405nm青紫色レーザー光を用いた口腔カンジダ症制御の可能性 (2013)
  • Author(s): 今村武浩 舘原誠晃 山近重生 手塚充樹 竹部祐生亮 徳山麗子 大島朋子 前田伸子 里村一人
  • Organizer: 日本口腔内科学会学術大会
  • Place of Presentation: 東京 如水会館
• [Presentation] 405nm青紫色レーザー光を用いた口腔カンジダ症制御の可能性 (2013)
  • Author(s): 今村武浩 舘原誠晃 手塚充樹 竹部祐生亮 徳山麗子 大島朋子 前田伸子 里村一人
  • Organizer: 日本口腔外科学会総会
  • Place of Presentation: 福岡 国際会議場
• [Presentation] Possible application of 405-nm blue light irradiation for the treatment and the prevention of oral candidiasis (2013)
  • Author(s): Takahiro Imamura, Seiko Tatehara, Yusuke Takebe, Reiko Tokuyama, Kazuhito Satomura
  • Organizer: International conference on oral and maxillofacial surgery
  • Place of Presentation: BARCELONA SPAIN