Development of new treatment strategy targeting for vascular niche of oral cancer stem cell
Project/Area Number |
25463106
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Surgical dentistry
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Research Institution | Hokkaido University |
Principal Investigator |
OHIRO Yoichi 北海道大学, 歯学研究科(研究院), 講師 (40301915)
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Co-Investigator(Kenkyū-buntansha) |
AKIYAMA Kousuke 北海道大学, 遺伝子制御研究所, 客員研究員 (10609100)
TEI Kanchu 北海道大学, 歯学研究科(研究院), 教授 (80180066)
進藤 正信 北海道大学, 歯学研究科(研究院), 教授 (20162802) [Withdrawn]
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 腫瘍血管内皮細胞 / がん幹細胞 / 薬剤抵抗性 |
Outline of Final Research Achievements |
Cancer stem cells (CSC) or matured cancer cells were fractionated from cancer cell lines. Tumor endothelial cells (TEC) were separated from transplanted tumors in vivo model. CSC were co-cultured with TEC or treated with TEC conditioned media (TEC-TM). These experiments revealed that activation of survival signal such as Akt or NF-kB, alteration of expression levels of CSC markers and inhibitory effect against apopotosis were induced in CSC. Furthermore, co-cultivation of CSC with TEC separated from highly metastatic tumor induce the formation of large sphenoid or inhibitory effect for anoikis by TEC.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Fibrosis in Preeclamptic Placentas Is Associated with Stromal Fibroblasts Activated by the Transforming Growth Factor-β1 Signaling Pathway.2018
Author(s)
J. Asai, H. Takenaka, S. Hirakawa, J. Sakabe, A. Hagura, S. Kishimoto, K. Maruyama, K. Kajiya, S. Kinoshita, Y. Tokura, N. Katoh
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Journal Title
American Journal of Pathology
Volume: 181
Pages: 1180-1189
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Suprabasin as a novel tumor endothelial cell marker.2014
Author(s)
3.Alam Mohammad Towfik,Nagao-Kitamoto H., Ohga N., Akiyama K., Maishi N., Kawamoto T., Shinohara N., Taketomi A., Shindoh M., Hida Y. and *Hida K
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Journal Title
Cancer Science
Volume: 105(12)
Pages: 1533-1540
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Lysyl oxidase secreted by tumour endothelial cells promotes angiogenesis and metastasis.2013
Author(s)
Osawa T., et al., Ohga N., Akiyama K., Hida Y., Kitayama K., Kawamoto T, , Yamamoto K., Maishi N., Kondoh M., Onodera Y., Fujie M., Nonomura K., Shindoh M., Hida K.
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Journal Title
Br J Cancer.
Volume: 109(8)
Pages: 2237-2247
DOI
NAID
Related Report
Peer Reviewed
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[Presentation] Vasohibin-1 as a novel prognostic factor in oral squamous cell carcinoma2014
Author(s)
Torii C., Ohga N., Akiyama K., Maishi N., Hojo T., Ohiro Y., Ono M., Totsuka Y., Kitagawa Y., Tei K., Hida Y., Shindoh M., Sato Y., Hida K
Organizer
The 18th International Vascular Biology Meeting
Place of Presentation
みやこめっせ(京都府、京都)
Year and Date
2014-04-14 – 2014-04-17
Related Report
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