Examination of the taste disorder associated with cancer chemotherapy in rats and humans.

• Project/Area Number: 25463112
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Nagasaki University
• Principal Investigator: FUJIYAMA Rie 長崎大学, 医歯薬学総合研究科(歯学系), 助教 (10274664)
• Co-Investigator(Kenkyū-buntansha): OKADA Yukio 長崎大学, 医歯薬学総合研究科(歯学系), 准教授 (60136687)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 味覚障害 / がん化学療法 / ヒト / ラット / 味覚嗜好性 / 化学療法

Outline of Final Research Achievements

The alteration in taste (dysgeusia) is a common and severe side effect in approximately 60% of cancer patients undergoing chemotherapy. However, research on this problem is lacking. The aim of the experiments was to investigate the effects of paclitaxel on voluntary sucrose or NaCl intake using a two bottle choice. Intraperitoneal administration of Paclitaxel decrease sucrose-solution intake and preference in a few days after we administrated it to rats. Furthermore the sweet-preference improved in several days after we stopped it to rats. Outcomes indicate Paclitaxel attenuates sweet-taste preference in two bottle choice. We could not observe any effects of paclitaxel on NaCl intake and preference such as the effect on sucrose. These results suggest that paclitaxel alters sucrose however not NaCl preference and there are different side effects of paclitaxel on the preference of NaCl and sucrose in rats. These findings indicate paclitaxel modifies the specific taste function.

Research Products

• [Journal Article] Carbenoxolone-sensitive and cesium-permeable potassium channel in the rod cells of frog taste discs. (2015)
  • Author(s): Okada Y，Miyazaki T，Fujiyama R，Toda K
  • Journal Title: Biochem Biophys Reports Volume: 4 Pages: 175-179
  • DOI: 10.1016/j.bbrep.2015.09.010
  • NAID: 120006986868
  • Peer Reviewed / Open Access
• [Journal Article] Paclitaxel chemotherapy affects sweet-preference in rats. (2015)
  • Author(s): Fujiyama, Rie, Okada, Yukio, Toda, Kazuo
  • Journal Title: The Journal of Physiological Sciences Volume: 65
  • Open Access
• [Presentation] 抗がん剤パクリタキセルによる高濃度食塩水忌避反応の変調 (2015)
  • Author(s): 高濱達生，藤山理恵，岡田幸雄，戸田一雄
  • Organizer: 第9回三叉神経領域の感覚-運動統合機構研究会
  • Place of Presentation: 休暇村志賀島（福岡）
  • Year and Date: 2015-11-28
• [Presentation] The effects of paclitaxel in regard to NaCl and sucrose preference in rats. (2015)
  • Author(s): Fujiyama R，Okada Y，Toda K
  • Organizer: The 8th Federation of Asian and Oceanian Physiological Societies Congress
  • Place of Presentation: Centra Grand and Bangkok Convention Center (Bangkok，Thailand)
  • Year and Date: 2015-11-22
  • Int'l Joint Research
• [Presentation] カエル味細胞のcalbenoxolone感受性カリウムチャネル (2015)
  • Author(s): 岡田幸雄，宮崎敏博，藤山理恵，戸田一雄
  • Organizer: 日本動物学会第86 回大会
  • Place of Presentation: 朱鷺メッセ（新潟）
  • Year and Date: 2015-09-17
• [Presentation] 抗がん剤パクリタキセルは甘味の嗜好性を抑制する (2015)
  • Author(s): 藤山理恵・岡田幸雄・戸田一雄
  • Organizer: 第92回日本生理学会大会
  • Place of Presentation: 神戸国際会議場・展示場（兵庫県神戸市）
  • Year and Date: 2015-03-21 – 2015-03-23
• [Presentation] 味覚感受性に与える冷刺激の影響：性差 (2013)
  • Author(s): 藤山理恵，岡田幸雄, 戸田一雄
  • Organizer: 第55回歯科基礎医学会学術大会・総会
  • Place of Presentation: 岡山市（岡山コンベンションセンター）
• [Book] 今日の臨床サポート（永井良三，福井次矢，木村健二郎，上村直実，桑島 巌，今井 靖， 嶋田 元編）（ウェブサイト：http://clinicalsup.jp/jpoc/） (2016)
  • Author(s): 藤山理恵
  • Total Pages: 10
  • Publisher: エルゼビア・ジャパン
• [Book] 今日の臨床サポート（永井良三、福井次矢、木村健二郎、上村直実、桑島巌、今井靖、嶋田元 編） ウェブサイト：http://clinicalsup.jp/jpoc/ (2015)
  • Author(s): 藤山理恵
  • Total Pages: 11
  • Publisher: エルゼビア・ジャパン
• [Book] 今日の臨床サポート(永井良三,福井次矢,木村健二郎,上村直実,桑島 巌,今井靖,嶋田元編)ウェブサイト：http://clinicalsup.jp/jpoc/ (2013)
  • Author(s): 藤山理恵
  • Publisher: エルゼビア・ジャパン