Basic and clinical study of new peptide vaccine therapy for patients with oral cancer
| Project/Area Number |
25463115
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Surgical dentistry
|
|---|
| Research Institution | Sapporo Medical University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Jun-ichi 札幌医科大学, 医学部, 助教 (80404739)
SASAKI Takanori 札幌医科大学, 医学部, 助教 (50548732)
FUJINO Junki 札幌医科大学, 医学部, 研究員 (60620945)
MICHIFURI Yoshitaka 札幌医科大学, 医学部, 研究員 (00457722)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Keywords | がんペプチドワクチン / がん抗原 / 口腔がん / サバイビン / がん免疫 / がんペプチワクチン |
|---|
| Outline of Final Research Achievements |
We described a sequential clinical trial of SVN-2B peptide vaccine therapy in combination with incomplete Freund’s adjuvant (IFA) and interferon (IFN)-alpha for patients with oral cancer. Results indicated that the combination therapy increased the frequency of peptide specific cytotoxic T lymphocytes (CTLs) more effectively than the peptide alone. This regimen may be useful as a new therapeutic modality.
We isolated oral cancer stem-like cells (CSCs) as aldehyde dehydrogenase 1 bright (ALDH1br) cells. SPRR1B gene was shown to be overexpressed in the ALDH1br cells, indicating that it has a role in cell growth and maintenance by suppression of RASSF4. Furthermore, we established an oral cancer cell line and an autologous CTL line. It was shown that the CTL line recognized autologous tumor cells in an HLA-A24-restricted manner. Precise analyses of the CTL-recognized antigens may provide us with substantial strategies toward developing a more effective cancer peptide vaccine.
|
Report
(4 results)
Research Products
(26 results)
-
[Journal Article] Microenvironmental stresses induce HLA-E/Qa-1 surface expression and thereby reduce CD8+ T-cell recognition of stressed cells2016
Author(s)
Sasaki T, Kanaseki T, Shionoya Y, Tokita S, Miyamoto S, Saka E, Kochin V, Takasawa A, Hirohashi Y, Tamura Y, Miyazaki A, Torigoe T, Hiratsuka H, Sato N
-
Journal Title
Eur J Immunol
Volume: 46
Issue: 4
Pages: 929-940
DOI
Related Report
Peer Reviewed
-
-
[Journal Article] Clinical outcomes of oral squamous cell carcinomas treated by surgery over 9 years : a comparison of results to those in a 2003 international collaborative study2015
Author(s)
平塚博義, 宮﨑晃亘, 出張裕也, 荻 和弘, 三木善樹, 小林淳一, 上田 愛, 五十嵐友彦,島西真琴, 仲盛健治, 宮川 明, 関口 隆, 井手 隆
-
Journal Title
札幌医学雑誌 = The Sapporo medical journal
Volume: 84
Issue: 1-6
Pages: 7-1
DOI
NAID
ISSN
0036-472X
URL
Related Report
Peer Reviewed
-
-
[Journal Article] Small proline-rich protein-1B is overexpressed in human oral squamous cell cancer stem-like cells and is related to their growth through activation of MAP kinase signal.2013
Author(s)
Michifuri Y, Hirohashi Y, Torigoe T, Miyazaki A, Fujino J, Tamura Y, Tsukahara T, Kanaseki T, Kobayashi J, Sasaki T, Takahashi A, Nakamori K, Yamaguchi A, Hiratsuka H, Sato N.
-
Journal Title
Biochem Biophys Res Commun
Volume: 439
Issue: 1
Pages: 96-102
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
