Immunochemotherapy combined with hyperthermia for distant metastases of oral cancer using magnetic anticancer drug
Project/Area Number |
25463116
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Surgical dentistry
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Research Institution | Yokohama City University |
Principal Investigator |
MITSUDO Kenji 横浜市立大学, 医学部, 准教授 (70303641)
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Co-Investigator(Kenkyū-buntansha) |
小栗 千里 横浜市立大学, 医学部, 助教 (30400394)
藤内 祝 横浜市立大学, 医学研究科, 教授 (50172127)
|
Project Period (FY) |
2013-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
Keywords | 温熱免疫化学療法 / 口腔癌の遠隔転移 / 新規磁性抗癌剤 / 口腔癌 / 遠隔転移 / 温熱療法 / 免疫賦活 / ヒト由来扁平上皮癌細胞株 / 口腔多発癌 / 重複癌 / ハイパーサーミア / 磁性抗癌剤 / アポトーシス / 電子顕微鏡 |
Outline of Final Research Achievements |
This study is to evaluate the immunostimulation activity treated with immunochemotherapy combined with local hyperthermia using new magnetic anticancer drug. We examined the expression of heat shock protein 70 and heat shock protein 90 (HSP70/HSP90) treated with 42.5 degree hyperthermia using magnetic anticancer drug in cultured human oral cancer cells. Expression of HSP70/HSP90 has been increased after local hyperthermia, indicating that immunostimulation activity is provided by hyperthermia. Cultured human oral cancer cells are inoculated on both side of the leg in nude mice and magnetic anticancer drug was injected into the left tumor. The leg tumor is irradiated with a magnetic field, the tumor-specific local hyperthermia induces decrease of both tumors after treatment. These results suggest that local hyperthermia treatment induced immunostimulation activity.
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Report
(5 results)
Research Products
(28 results)
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[Journal Article] Simultaneous hyperthermia-chemotherapy with controlled drug delivery using single-drug nanoparticles2016
Author(s)
Itaru Sato, Masanari Umemura, Kenji Mitsudo, Hidenobu Fukumura, Jeong-Hwan Kim, Yujiro Hoshino Hideyuki Nakashima, Mitomu Kioi, Rina Nakakaji, Motohiko Sato, Takayuki Fujita, Utako Yokoyama, Satoshi Okumura, Hisashi Oshiro, Haruki Eguchi, Iwai Tohnai and Yoshihiro Ishikawa.
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Journal Title
Scientific reports
Volume: 6
Issue: 1
Pages: 24629-24629
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Simultaneous hyperthermia-chemotherapy with controlled drug delivery using single-drug nanoparticles.2016
Author(s)
Sato I, Umemura M, Mitsudo K, Fukumura H, Kim J-H, Hoshino Y, Nakashima H, Kioi M, Nakakaji R, Sato M, Fujita T, Yokoyama U, Okumura S, Eguchi H, Oshiro H, Tohnai I, Ishikawa Y
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Journal Title
Scientific Reports
Volume: in press
Related Report
Peer Reviewed
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[Journal Article] Prognostic value of 2-[18 F]fluoro-2-deoxy-D-glucose positron emission tomography for patients with oral squamous cell carcinoma treated with retrograde superselective intraarterial chemotherapy and daily concurrent radiotherapy.2016
Author(s)
Shimizu M, Mitsudo K, Koike I, Taguri M, Iwai T, Koizumi T, Oguri S, Kioi M, Hirota M, Inoue T, Tohnai I.
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Journal Title
Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology
Volume: 142
Issue: 3
Pages: 239-247
DOI
Related Report
Peer Reviewed
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[Journal Article] Retrograde intra-arterial chemotherapy and daily concurrent proton beam therapy for recurrent oral cavity squamous cell carcinoma: Analysis of therapeutic results in 46 cases.2016
Author(s)
Hayashi Y, Nakamura T, Mitsudo K, Yamaguchi H, Ono T, Azami Y, Takayama K, Suzuki M, Hatayama Y, Tsukiyama I, Hareyama M, Kikuchi Y, Fuwa N, Tohnai I.
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Journal Title
Head Neck.
Volume: 未定
Issue: 8
Pages: 1145-1151
DOI
Related Report
Peer Reviewed
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[Journal Article] Increase of Peripheral Blood CD57+ T-Cells in Patients with Oral Squamous Cell Carcinoma.2014
Author(s)
Iida M, Takayama E, Naganawa K, Mitsudo K, Adachi M, Baba J, Fujimoto-Muto M, Motohashi M, Mizuno-Kamiya M, Kawaki H, Kioi M, Ichinose M, Sumitomo S, Muramatsu Y, Shikimori M, Tohnai I, Kondoh N.
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Journal Title
Anticancer Res
Volume: 9
Issue: 1
Pages: 5729-5734
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Retrograde superselective intra-arterial chemotherapy and daily concurrent radiotherapy for stage III and IV oral cancer: Analysis of therapeutic results in 112 cases2014
Author(s)
Mitsudo K, Koizumi T, Iida M, Iwai T, Nakashima H, Oguri S, Kioi M, Hirota M, Koike I, Hata M, Tohnai I
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Journal Title
Radiother Oncology
Volume: 111
Pages: 306-310
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] Organ preservation with daily concurrent chemoradiotherapy using retrograde superselective intra-arterial infusion for locally advanced tongue cancer: analysis of therapeutic results in 101 cases2016
Author(s)
Mitsudo K, Oguri S, Minamiyama S, Iida M, Iwai T, Nakashima H, Koizumi T, Kioi M, Hirota M, Tohnai I
Organizer
2016 American Society of Clinical Oncology Annual Meeting
Place of Presentation
Chicago, USA
Year and Date
2016-06-02
Related Report
Int'l Joint Research
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[Presentation] Hyperthermia enhances the therapeutic efficacy of IL-13 cytotoxin in human oral squamous cell carcinoma.2016
Author(s)
Nakashima H, Okubo M, Kioi M, Miyajima A, Iisaka T, Sugiura K, Itaru S, Koizumi T, Mitsudo K, Tohnai I
Organizer
The 12th International congress of hyperthermic oncology
Place of Presentation
New Orleans, USA
Year and Date
2016-04-11
Related Report
Int'l Joint Research
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[Presentation] Clinical evaluation of thermochemoradiotherapy using retrograde superselective intra-arterial infusion for advanced oral squamous cell carcinoma with cervical lymph node metastases2014
Author(s)
Iida M, Mitsudo K, Ohara Y, Ohya T, Koizumi T, Nakashima H, Iwai T, Oguri S, Kioi M, Hirota M, Tohnai I
Organizer
6th Asian Congress of Hyperthermic Oncology
Place of Presentation
福井県県民ホール(福井県福井市)
Year and Date
2014-09-05 – 2014-09-06
Related Report
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[Presentation] Novel thermo-chemotherapy using a new magnetic anti-cancer drug.2013
Author(s)
Sato I, Umemura M, Mitsudo K, Feng X, Nakashima H, Kioi M, Eguchi H, Tohnai I, Ishikawa Y.
Organizer
American Association for Cancer Research (AACR) Annual Meeting 2013.
Place of Presentation
Washington, DC, USA
Related Report
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