| Project/Area Number |
25463121
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Surgical dentistry
|
|---|
| Research Institution | Tokyo Medical University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
續 雅子 東京医科大学, 医学部, 兼任講師 (40385092)
里見 貴史 東京医科大学, 医学部, 臨床准教授 (70276921)
|
|---|
| Project Period (FY) |
2013-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
|---|
| Keywords | 口腔扁平上皮癌 / 上皮間葉移行 / 抗癌剤感受性 / 組織学的悪性度 / miRNA / 腫瘍幹細胞 / 抗癌剤代謝酵素 |
|---|
| Outline of Final Research Achievements |
The expression of targeting metabolic enzymes of fluoropyrimidine was investigated in oral squamous cell carcinoma. The quantity of expression in metabolic enzymes (OPRT, TS, and TP) influenced the response to the antitumor agent. Meanwhile, it has been indicated that tumor stem like cells could have resistance to therapy and be regarded with epithelial-mesenchymal trnsition. Therefore, the relation with the sensitivity to antitumor agent and the markers (vimentin, snail, and E-cadherin) of epithelial-mesenchymal trnsition was studied histopathologically. There was strong positivity of their markers in the non-response cases.
In examination of the presence of miRNA targeting genes of metabolic enzymes that change in expression, the identification was attempted by mean of the difference of miRNA expression using the profile analysis. However, it was not elucidated miRNA that targets genes of metabolic enzymes
|
