| Project/Area Number |
25463122
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Tsurumi University |
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Principal Investigator |
SATO Toru 鶴見大学, 歯学部, 学内准教授 (30170765)
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| Co-Investigator(Kenkyū-buntansha) |
KAMIYA Yoko 鶴見大学, 歯学部, 非常勤講師 (10460213)
TERADA Chika 鶴見大学, 歯学部, 学部助手 (40460216)
SATOMURA Kazuhito 鶴見大学, 歯学部, 教授 (80243715)
片岡 志基 鶴見大学, 歯学部, 臨床助手 (80624676)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 舌癌 / TNM分類 / 深達度 / リンパ節転移 / リンパ管 / 解剖実習用遺体 / 口腔癌 / 癌深達度 / D2-40 / 血管 / CD34 / VEGF |
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| Outline of Final Research Achievements |
In order to clarify the topography of lymph vessels in non-cancerous oral tongue, immunohistochemistry of D2-40 was applied to the anterior, middle and posterior part of oral tongue from archival cadavers. Lymphatic vessel density(LVD), lymphatic vessel perimeter(LVP) were measured in upper subepithelial layer(UC), lower subepithelial layer(LC), superficial muscle layer(SM), and deep muscle layer(DM). LVD and LVP were the highest in UC followed by LC, and greatly reduced in SM and DM in any site of anterior, middle, posterior part. There were no differences of LVD and LVP between SM and DM in any site. Anterior part was the highest LVD and LVP, and posterior part was the lowest LVD and LVP in any depth.
Additionally, in resected StageⅠ tongue cancer, there was no remarkable difference of lymph vessel distribution between positive and negative cases with subsequent metastases. Subepithelial lymph vessel proliferation beneath the peritumoral epithelial dysplasia was unremarkable.
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