The roles of catecolaminergic neuron in relationships Diffuse Noxiou Inhibitory Controls and chronic pain

• Project/Area Number: 25463128
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Meikai University (2014-2015); Tokyo Medical and Dental University (2013)
• Principal Investigator: KOHASE Hikaru 明海大学, 歯学部, 教授 (20251548)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 広範囲侵害性抑制性調節 / 下行性抑制系 / 広範囲侵害性抑制 / 条件疼痛変調 / DNIC / CPM / pain modulation / 下降性抑制系 / Pain Modulation

Outline of Final Research Achievements

Diffuse Noxious Inhibitory Controls (DNIC) or Conditioned Pain Modulation (CPM) is a phenomenon that the effects of a noxious stimuli in inhibited by heterotopic noxious stimuli. Descending inhibitory controls, including catecholamine neuron system, are not well investigated. Systemic administration of Phenylephrine (PE α1-adrenoceptor agonist) is found to inhibit diffuse noxious inhibitory control (DNIC) in rats. The further study was designed to investigate the effect of intravenous administration of PE on CPM in humans.The study shows that systemic administration of an α1-adrenoceptor agonist (PE), the lower clinical dose, inhibited CPM in humans. These results may provide some mechanistic insight into why many chronic pain patients show impaired CPM. On the basis of the results, The next study shows that temporomandibular disorders (TMD) patients with temporomandibular joint (TMJ) pain had different conditioned pain modulation (CPM) compared with healthy subjects.

Research Products

• [Journal Article] Conditioned pain modulation in temporomandibular disorders (TMD) pain patients. (2014)
  • Author(s): Oono Y, Wang K, Baad-Hansen L, Futarmal S, Kohase H, Svensson P, Arendt-Nielsen L.
  • Journal Title: Exp Brain Res. Volume: 232(10) Issue: 10 Pages: 3111-9
  • DOI: 10.1007/s00221-014-3997-7
  • Peer Reviewed
• [Journal Article] The effectiveness of a mouth guard to protect against strong occlusion caused by modified electroconvulsive therapy (2014)
  • Author(s): Saori Ogami, Morimasa Yamada, Mayuko Kanazawa, Kiyoshi Takeda, Naoaki Kimura, Hideki Mizutani, Hikaru Kohase
  • Journal Title: Dental Traumatology Volume: Online version Issue: 5 Pages: 1-6
  • DOI: 10.1111/edt.12097
  • Peer Reviewed
• [Presentation] あらたに開発した定量的熱刺激装置 (2015)
  • Author(s): 今村敏克、上杉典子、竹内菊子、星島宏、西澤秀哉、内田茂則、山西優一郎、小林克江、鈴木佐知子、黒田翔太、大野由夏、大上沙央理、長坂浩、長谷川彰彦、小長谷光
  • Organizer: 日本歯科麻酔学会
  • Place of Presentation: 東京
  • Year and Date: 2015-10-31
• [Presentation] Conditioned pain modulation in healthy volunteers evaluated with a new custom-made quantitative cold pain stimulator (2015)
  • Author(s): Yuka Oono,Toshikatsu Imamura,Saori Ogami, Akihiko Hasegawa,Hiroshi Nagasaka,Kelun Wang,Lars Arendt-Nielsen,Hikaru Kohase
  • Organizer: EFIC 2015
  • Place of Presentation: Viena Austria
  • Year and Date: 2015-09-02
  • Int'l Joint Research
• [Presentation] あらたに開発した定量的熱刺激装置を用いたCPM評価 (2015)
  • Author(s): 今村 敏克、大野 由夏、大上 沙央理、長坂 浩、小長谷 光
  • Organizer: 日本麻酔科学会
  • Place of Presentation: 神戸
  • Year and Date: 2015-05-28
• [Presentation] The reliability of new pressure algometer in measuring pressure pain threshold in human studies (2014)
  • Author(s): Y. Oono, H. Kohase, Katsuhiro Matsumoto, Kelun Wang, Lars Arendt-Nielsen
  • Organizer: World Congress on Pain International Association for the Study of Pain
  • Place of Presentation: Buenos Aires, Argentina
  • Year and Date: 2014-10-03 – 2014-10-10
• [Presentation] Conditioned pain modulation in temporomandibular disorders patients (2013)
  • Author(s): Oono, Yuka; Wang, Kelun; Baad-Hansen, L.; Futarmal, S.; Ogami, S.; Matsumoto, K.; Fukayama, H.; Kohase, H.; Svensson, P.; Arendt-Nielsen, Lars
  • Organizer: 8th Congress of the European Federation of IASP Chapters (EFIC)
  • Place of Presentation: Florance Italy
• [Presentation] 意図的レミフェンタニル濃度維持による、静穏な全身麻酔からの覚醒 (2013)
  • Author(s): 小長谷 光, 市川 怜那, 田草川 裕子, 熊坂 祝, 大野 由夏, 大上 沙央理
  • Organizer: 日本歯科麻酔学会総会
  • Place of Presentation: 横浜
• [Presentation] 遺伝性血管性浮腫(HAE)を有する小児患者の全身麻酔経験 (2013)
  • Author(s): 水谷 文子, 松村 朋香, 小長谷 光, 深山 治久
  • Organizer: 日本歯科麻酔学会総会
  • Place of Presentation: 横浜