| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Diffuse Noxious Inhibitory Controls (DNIC) or Conditioned Pain Modulation (CPM) is a phenomenon that the effects of a noxious stimuli in inhibited by heterotopic noxious stimuli. Descending inhibitory controls, including catecholamine neuron system, are not well investigated. Systemic administration of Phenylephrine (PE α1-adrenoceptor agonist) is found to inhibit diffuse noxious inhibitory control (DNIC) in rats. The further study was designed to investigate the effect of intravenous administration of PE on CPM in humans.The study shows that systemic administration of an α1-adrenoceptor agonist (PE), the lower clinical dose, inhibited CPM in humans. These results may provide some mechanistic insight into why many chronic pain patients show impaired CPM. On the basis of the results, The next study shows that temporomandibular disorders (TMD) patients with temporomandibular joint (TMJ) pain had different conditioned pain modulation (CPM) compared with healthy subjects.
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